Liver Disease in Adults With Alpha-1 AT Deficiency (LIDIA-A1AT)
This cohort study will evaluate the prevalence of the infra clinical liver injuries among a group of adult patients presenting with Alpha-1 AT deficiency followed up in a large university hospital in Lyon, France.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Screening
|Official Title:||Research of Infra Clinical Liver Injuries in Adult Patients Presented With Alpha-1 AT Deficiency|
- The prevalence of infra clinical liver injuries [ Time Frame: At least one day depending on the schedule of the exams ] [ Designated as safety issue: No ]The prevalence of infra clinical liver injuries (lesions or liver abnormalities) in a cohort of adult patients presenting an Alpha-1 AT deficiency. Suspicion of fibrosis was defined as liver stiffness > 7.2kPa measured by transient elastography (TE).
- morphological liver complications description [ Time Frame: At least one day depending on the schedule of the exams ] [ Designated as safety issue: No ]To describe all the morphological liver complications present at the moment of the investigation.
- measure of biological parameters [ Time Frame: At least one day depending on the schedule of the exams ] [ Designated as safety issue: No ]- To measure the biological parameters (as AST, ALT, GGT, total bilirubin, lymphocytes, platelets, FibroTest score) and radiological aspects (TE score, liver aspect evaluated by ultrasound)
|Study Start Date:||May 2011|
|Study Completion Date:||March 2012|
|Primary Completion Date:||March 2012 (Final data collection date for primary outcome measure)|
|Transient elastography and fibrotest||
Other: Transient Elastography and fibrotest
a Transient Elastography and an ultrasound are performed.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01455298
|Hôpital Femme Mère Enfant - Hospices Civils de Lyon|
|Bron, France, 69677|
|Principal Investigator:||Jean-François MORNEX, PhD, MD||Hospices Civils de Lyon|