Heart Rate Variability of Patients With Bipolar Disorder in Subsyndromal Depressive Phase
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Purpose
The purposes of this study were: (1) to compare heart rate variability between bipolar patients in subsyndromal depressive phase and healthy controls (2) to evaluate the relation between the severity of subsyndromal depressive symptoms and reduced heart rate variability.
| Condition |
|---|
|
Bipolar Disorder Subsyndromal Depressive Phase Heart Rate Variability |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Heart Rate Variability of Patients With Bipolar Disorder in Subsyndromal Depressive Phase |
- Heart rate variability (HRV) [ Time Frame: at baseline ] [ Designated as safety issue: No ]
Time domain - NN (normal-to-normal R-R interval), HRV index (total number of all NN/ the height of the histogram of all NN), SDNN (standard deviation of the NN), RMSSD (the root mean square of differences of successive NN), NN50 (Number of pairs of adjacent NN intervals differing by more than 50 ms in the entire recording) and pNN50(NN50/total number of all NN).
Frequency domain - TP (The variance of NN intervals over the temporal segment), VLF(Power in very low frequency range; <0.04 Hz), LF(Power in low frequency range; 0.04~0.15 Hz), HF(Power in high frequency range; 0.15~0.4 Hz)
| Enrollment: | 92 |
| Study Start Date: | January 2010 |
| Study Completion Date: | April 2010 |
| Primary Completion Date: | April 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Control group
Healthy controls had no history of psychiatric disorder and had no psychiatric symptom when interviewed by a board-certified psychiatrist.
|
|
Bipolar group
individual patient as being in subsyndromal depressive phase when the patient had a Montgomery-Åsberg depression rating scale score of 10 or less and Clinical Global Impression severity of 3 or less for last one month.
|
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Thirty three (10 males, 23 females) patients in clinically remitted state diagnosed with bipolar disorder based on DSM-IV criteria were enrolled at one outpatient psychiatric clinic and 59 healthy controls (23 males, 36 females) from health promotion center in a university-affiliated general hospital. We defined an individual patient as being in subsyndromal depressive phase when the patient had a Montgomery-Åsberg depression rating scale (MADRS) score of 10 or less and Clinical Global Impression severity (CGI-S) of 3 or less for last one month. Healthy controls had no history of psychiatric disorder and had no psychiatric symptom when interviewed by a board-certified psychiatrist.
Inclusion Criteria:
Bipolar group:
- DSM-IV bipolar disorder
- Montgomery-Åsberg depression rating scale (MADRS) score for last one month : ≤ 10
- Clinical Global Impression severity (CGI-S) for last one month : ≤ 3
- Healthy controls group: Subjects had no history of psychiatric disorder and had no psychiatric symptom when interviewed by a board-certified psychiatrist.
Exclusion Criteria:
- Psychiatric disorder except bipolar disorder
- Neurological symptoms or signs
- History of head trauma
- History of cardiovascular diseases
- Any medication except psychiatric medication.
Contacts and Locations More Information
No publications provided
| Responsible Party: | Yeon-Ho Joo, Professor, Asan Medical Center |
| ClinicalTrials.gov Identifier: | NCT01455038 History of Changes |
| Other Study ID Numbers: | A090116 |
| Study First Received: | October 18, 2011 |
| Last Updated: | October 18, 2011 |
| Health Authority: | Korea: Institutional Review Board |
Additional relevant MeSH terms:
|
Bipolar Disorder Affective Disorders, Psychotic Mood Disorders Mental Disorders |
ClinicalTrials.gov processed this record on May 23, 2013