Text Size

Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese (TRENO)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT01453972
First received: October 10, 2011
Last updated: April 9, 2013
Last verified: April 2013
History of Changes
  Purpose

The main purpose of our study is to examine the physiological adaptations in oxygen transport chain for high-intensity exercise and moderate exercise in overweight and obese humans. The main goals are:

  1. To investigate the most effective short-and long-interval training in terms of VO2max, pulmonary diffusion, cardiac output, endothelial function and mitochondrial function.
  2. How these physiological adaptations affect the aerobic endurance and performance, and how this training can reduce the risk of cardiovascular diseases related to overweight and obesity.

Condition Intervention
Overweight
Obesity
 Behavioral: Long distanse moderate training
Behavioral: Long interval training
Behavioral: Short interval training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Maximal oxygen uptake [ Time Frame: 6 weeks ] [ Designated as safety issue: No ]
    Change in maximal oxygen uptake will be measured after six weeks of various exercise training and related to changes in blood volume, cardiac function, endothelial function and mitochondrial function.


Enrollment: 30
Study Start Date: October 2011
Study Completion Date: December 2012
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Long distanse moderate training
40 minutes moderate treadmill running
 Behavioral: Long distanse moderate training
Moderate exercise
Experimental: Long interval training
4x4min interval treadmill running
 Behavioral: Long interval training
High-intensity exercise, long duration
Experimental: Short interval training
10x1min interval treadmill running
 Behavioral: Short interval training
High intensity exercise, short duration

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI > 25

Exclusion Criteria:

  • Exclusion criteria will be cardiovascular disease or another disease that is not consistent with high physical activity. Subjects should not have exercised regularly before the study.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01453972

Locations
Norway
Medical Faculty, Norwegian University of Science and Technology
Trondheim, Sør-Trøndelag, Norway, 7491
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Principal Investigator: Øivind Rognmo, PhD Norwegian University of Science and Technology
  More Information

No publications provided

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT01453972     History of Changes
Other Study ID Numbers: TRENO
Study First Received: October 10, 2011
Last Updated: April 9, 2013
Health Authority: Norway: Regional Ethics Commitee

Keywords provided by Norwegian University of Science and Technology:
Exercise
High-intensity
Interval training

Additional relevant MeSH terms:
Obesity
Overweight
Overnutrition
 Nutrition Disorders
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on May 23, 2013