Lymphocytic Herpesviruses and Cerebrospinal Fluid Polymerase Chain Reaction (PCR)
Enterovirus and herpes simplex viruses 1 and 2 are the main causative agents of central nervous system infections.
Instead, the role of lymphocytic herpesviruses in the etiology of central nervous system (CNS) infections is not clear, even if there is the positive cerebrospinal fluid (CSF) polymerase chain reaction (PCR)-result for the virus.
The aim of this study is to evaluate the presence of DNA from lymphocytic herpesviruses in the CSF obtained from the immunocompetent patients with CSF pleocytosis and from the patients with normal CSF leukocyte count.
Central Nervous System Infection
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Molecular Methods in the Etiological Diagnostics of Acute Central Nervous System Infections: Lymphocytic Herpesviruses and PCR|
CSF white cells + CSF supernatant, Blood white cells and serum
|Study Start Date:||October 2011|
|Estimated Study Completion Date:||December 2013|
|Estimated Primary Completion Date:||October 2013 (Final data collection date for primary outcome measure)|
40 patients with clinical signs of CNS infection and having CSF pleocytosis.
20 patients not having CNS infection clinically and not having CSF pleocytosis.
|Contact: Laura MA Kupilafirstname.lastname@example.org|
|PaijatHame Central Hospital||Not yet recruiting|
|Lahti, Finland, 15850|
|Contact: Laura Kupila email@example.com|
|Principal Investigator: Laura Kupila|
|Principal Investigator:||Laura MA Kupila||PaijatHame Central Hospital|