Desflurane Versus Propofol in the Sitting Position

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Hyun Jeong Kwak, Gachon University Gil Medical Center
ClinicalTrials.gov Identifier:
NCT01436799
First received: September 15, 2011
Last updated: August 25, 2013
Last verified: August 2013
  Purpose

The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.


Condition Intervention
Cerebral Ischemia
Drug: propofol
Drug: Desflurane
Drug: alfentanil
Drug: Rocuronium

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Prevention
Official Title: International Review Board of Gachon University Gil Hospital

Resource links provided by NLM:


Further study details as provided by Gachon University Gil Medical Center:

Primary Outcome Measures:
  • Regional Cerebral Oxygen Satuation (rSO2) [ Time Frame: 1, 3, 5, 7, and 9 min after the beach chair position ] [ Designated as safety issue: Yes ]
    definitive values of regional cerebral oxygen saturation(rSO2,%) values are described as mean (SD)


Enrollment: 40
Study Start Date: March 2011
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Desflurane
anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane
Drug: Desflurane
anaesthesia was maintained by desflurane 4-7vol%
Other Name: Des
Drug: alfentanil
administration of alfentanil 10 μg kg-1 for anesthetic induction
Other Name: alf
Drug: Rocuronium
administration of rocuronium 0.6 mg kg-1 for anesthetic induction
Other Name: roc
Active Comparator: propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model
Drug: propofol
anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1 mainly.
Other Name: propofol
Drug: alfentanil
administration of alfentanil 10 μg kg-1 for anesthetic induction
Other Name: alf
Drug: Rocuronium
administration of rocuronium 0.6 mg kg-1 for anesthetic induction
Other Name: roc

Detailed Description:

The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.

  Eligibility

Ages Eligible for Study:   20 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Forty patients,
  • ASA class I or II,
  • undergoing shoulder arthroscopy

Exclusion Criteria:

  • Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01436799

Sponsors and Collaborators
Gachon University Gil Medical Center
Investigators
Study Director: Hyun Jeong Kwak, MD.PhD Gachon University Gil Hospital
  More Information

No publications provided

Responsible Party: Hyun Jeong Kwak, Associate professor, Gachon University Gil Medical Center
ClinicalTrials.gov Identifier: NCT01436799     History of Changes
Other Study ID Numbers: GIRBA2466
Study First Received: September 15, 2011
Results First Received: February 5, 2013
Last Updated: August 25, 2013
Health Authority: Korea: Institutional Review Board

Keywords provided by Gachon University Gil Medical Center:
propofol
desflurane
cerebrovascular circulation
sitting

Additional relevant MeSH terms:
Cerebral Infarction
Brain Diseases
Brain Infarction
Brain Ischemia
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Nervous System Diseases
Stroke
Vascular Diseases
Alfentanil
Desflurane
Propofol
Rocuronium
Analgesics
Analgesics, Opioid
Anesthetics
Anesthetics, General
Anesthetics, Inhalation
Anesthetics, Intravenous
Central Nervous System Agents
Central Nervous System Depressants
Hypnotics and Sedatives
Narcotics
Neuromuscular Agents
Neuromuscular Blocking Agents
Neuromuscular Nondepolarizing Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on October 21, 2014