Pneumococcal Adult Kinetics Study - Understanding the B Cell Response to Pneumococcal Vaccines

Inclusion Criteria:

• Above 18 years of age.
• Participant is willing and able to give informed consent for participation after the nature of the study has been explained;

• In good health as determined by:

  • medical history
  • history-directed physical examination
  • clinical judgment of the investigator
• Able (in the Investigators opinion) and willing to comply with all study requirements including be available for all the visits scheduled in the study
• Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study.

Exclusion Criteria:

• Have previously received a pneumococcal vaccine
• Have received vaccination with a vaccine containing either CRM197 or diphtheria toxoid within the past 12 months,
• Have had previous ascertained disease caused by C. diphtheriae, or S. pneumoniae in the past 5 years documented in their medical notes
• Have a history of any anaphylactic shock, asthma, urticaria or other allergic reaction after previous vaccinations or known hypersensitivity to any vaccine component;

• Have a known or suspected autoimmune disease or impairment /alteration of immune function resulting from (for example):

  • Receipt of immunostimulants
  • Congenital or acquired immunodeficiency, or receipt of immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding 6 months or long-term systemic corticosteroid therapy (prednisolone or equivalent for more than two consecutive weeks within the past 3 months).
• Have a suspected or known HIV infection or HIV related disease;
• Have received blood, blood products and/or plasma derivatives or any parenteral immunoglobulin preparation in the past 3 months
• Have a known bleeding diathesis, or any condition that may be associated with a prolonged bleeding time;
• Have any condition, which, in the opinion of the investigator, might interfere with the evaluation of the study objectives.
• Participation in another clinical trial investigating a vaccine, a drug, a medical device, or a medical procedure
• Pregnancy as confirmed by a positive pregnancy test