FDG-PET/CT for Simulation and Radiation Treatment Planning of Early Breast Cancer
The purpose of the study is:
- to assess the potential benefits of 18F-[FDG] PET/CT and PET/MRI for operable breast cancer in order to define the size and location of the primary tumor, as well as axillary, supraclavicular and internal mammary lymph nodes.
- to apply the imaging results to the simulation and the radiation treatment planning and partial breast for 3-D radiation treatment and partial breast irradiation with intensity modulated radiation treatment (IMRT).
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Application of 18F-[FDG] PET/CT to Simulation and Planning of Radiotherapy (RT) for Breast Cancer. Definition of Target Volume for 3-D RT and for Partial Breast Irradiation (PBI) by IMRT Technique|
- Drawing of target volumes [ Time Frame: Up to 12 weeks after surgery ] [ Designated as safety issue: No ]Compare the drawing of target volumes using the PET/CT, PET/IRM information, or without these imaging informations.
- Correlate the FDG PET/CT PET/IRM with surgical pathology findings [ Time Frame: Up to 12 weeks after surgery ] [ Designated as safety issue: No ]Compare the pre-operative imaging information with histopathological description of the resected primary tumor, and with the extent of lymph node involvement.
|Study Start Date:||November 2007|
|Estimated Study Completion Date:||December 2014|
|Primary Completion Date:||May 2013 (Final data collection date for primary outcome measure)|
Pre-operative FDG PET/CT, and in option PET/IRM, are intended for women with histologically confirmed operable clinically node-negative breast cancer, in whom breast conserving and post-operative radiotherapy are planned.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01432002
|Radiation oncology, Geneva University Hospitals|
|Geneva, Switzerland, 1205|
|Principal Investigator:||Vincent Vinh-Hung, MD, PhD||Radiation Oncology, Geneva University Hospitals|