Does Coronary Angiography Cause Cognitive Dysfunction?
Recruitment status was Not yet recruiting
The purpose of the study is to study if coronary angiography cause cognitive dysfunction.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Study of Cognitive Function Before and After Coronary Angiography|
- Change in cognitive dysfunction from baseline to two days after coronary angiography [ Time Frame: Baseline and two days ] [ Designated as safety issue: Yes ]The Montreal Cognitive Assesment test will be performed before, 2 and 30 days after coronary angiography
- Number of patients with cerebral microemboli [ Time Frame: Baseline ] [ Designated as safety issue: Yes ]Cerebral microembolism will be studied by transcraniell doppler at the time of angiography. Findings will be related to change in cognitive function between baseline and two days.
|Study Start Date:||September 2011|
|Estimated Study Completion Date:||May 2012|
|Estimated Primary Completion Date:||February 2012 (Final data collection date for primary outcome measure)|
Patents scheduled for elective coronary angiography
Procedure: Arterial approach
Randomization to right radial or femoral approach
Other Name: Coronary arteriography
We have previously shown, using transcranial doppler, that coronary angiography cause cerebral microembolism. Cerebral microemboli were more common using the radial than femoral approach. Previously, cerebral microembolism has been associated with new cerebral lesions on MRI. The clinical significance of these new lesions is not determined. The primary aim of this pilot study is to see if coronary angiography cause cognitive dysfunction determined by the MoCA-test. A secondary aim is to relate cognitive dysfunction to cerebral microembolism measured by transcranial doppler. A third aim is to study potential differences between the femoral and radial approaches.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01428947
|Contact: Per - Tornvall, MD, PhD||+46-8-51772951 ext -||firstname.lastname@example.org|
|Cardiology Clinic, Karolinska University Hospital||Not yet recruiting|
|Stockholm, Sweden, 17176|
|Contact: Per - Tornvall, MD, PhD +46-8-51772951 ext - email@example.com|
|Sub-Investigator: Nondita - Sarkar, MD, PhD|
|Sub-Investigator: Juliane - Jurga, MD|
|Sub-Investigator: Jan - van der Linden, MD, PhD|
|Principal Investigator:||Per - Tornvall, MD, PhD||Karolinska Institutet|