Berlin Beat of Running Study
This prospective observational study will investigate the frequency of new onset atrial fibrillation (AF) and of further cardiac arrhythmias as well as of (clinically silent) cerebral lesions in endurance runners before, during and after the BMW-Berlin Marathon 2011.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Berlin Beat of Running Study - Frequency of Cardiac Arrhythmias & Cerebral Lesions in Marathon Runners|
- Rate of cardiac arrhythmias in marathon runners detected by mobile ECG-recording [ Time Frame: Up to 48 hours after the marathon race. ] [ Designated as safety issue: No ]During ECG recording
- Rate of (clinically silent) cerebral lesions detected by 3 Tesla brain MRI. [ Time Frame: 3 days ] [ Designated as safety issue: No ]Up to 3 days after marathon.
Biospecimen Retention: Samples Without DNA
Whole blood samples
|Study Start Date:||September 2011|
|Study Completion Date:||September 2012|
|Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
Up to 120 experienced marathon runners will participate in the "Berlin Beat of Running Study" and will wear a transportable electrocardiogram (ECG) recorder at least 24 hours before, during and 24 hours after the BMW-Berlin Marathon. All participants will undergo brain MRI examinations to detect cerebral lesions within days before and after the marathon race, respectively. Moreover, serial blood samples will be taken a few days before, immediately after as well as a few days after the BMW-Berlin Marathon.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01428778
|Center for Stroke Research Berlin|
|Principal Investigator:||Karl Georg Haeusler, MD||Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany.|
|Study Chair:||Matthias Endres, MD||Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany|
|Study Chair:||Wilhelm Haverkamp, MD||Departement of Cardiology, Campus Virchow, Charité - Universitätsmedizin Berlin, Germany|
|Study Chair:||Matthias Kruell, MD||Medical Institute BMW-Berlin Marathon|
|Study Chair:||Peter U Heuschmann, MD||Center for Stroke Research Berlin|
|Principal Investigator:||Gerhard Jan Jungehuelsing, MD||Center for Stroke Research Berlin|