Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Juma Alkaabi, United Arab Emirates University
ClinicalTrials.gov Identifier:
NCT01422668
First received: August 18, 2011
Last updated: August 23, 2011
Last verified: August 2011
  Purpose

The aim of this study was to evaluate the composition of Khalas, a very common type of dates used in the UAE and to determine the effects of drinking Arabic coffee on the results of GI tests in both healthy and diabetic subjects.


Condition Intervention Phase
Diabetes Mellitus
Other: Khalas dates
Phase 3

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Official Title: Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects

Resource links provided by NLM:


Further study details as provided by United Arab Emirates University:

Primary Outcome Measures:
  • Glycemic Index of Khalas dates with and without coffee [ Time Frame: 2 or 3 hours ] [ Designated as safety issue: No ]
    Every subject recieved 50 grams reducing sugars of Khalas dates with and without coffee. Measuring glucose level over 2 hours in Healthy subjects and over 3 hours in diabetic subjects as per a standard protocol.


Enrollment: 23
Study Start Date: March 2010
Study Completion Date: June 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: GI of Khalas dates
The Glycemic indices of the Khalas dates were measured for healthy and diabetic subjects.
Other: Khalas dates
every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates
Other Name: Khalas dates
Experimental: GI of the Khalas dates with Coffee
measuring the effect of 100 ml of coffee consumption on the GI of the Khalas dates among healthy and diabetic subjects.
Other: Khalas dates
every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates
Other Name: Khalas dates

Detailed Description:

Background:The consumption of dates along with coffee is a deeply rooted habit in many societies. This study was designed to determine the effect of coffee consumption on the glycemic index of a common variety of dates (Khalas) tested in healthy subjects and individuals with type 2 diabetes mellitus.

Methods:Composition analysis was carried out for Khalas dates (Tamer stage) and the weight of the dates flesh equivalent to 50 g of available carbohydrate was calculated. The study subjects were thirteen healthy volunteers with a mean (± SD) age of 40.2 ± 6.7 years and ten participants with type 2 diabetes mellitus (controlled on lifestyle measures and/or metformin) with a mean HbA1c (± SD) of 6.6 ± (0.7 %) and a mean age (± SD) of 40.8 ± 5.7 years. Each subject was tested on five separate days with 50 g of glucose (on 3 occasions) and 50 g equivalent of available carbohydrates from the dates without coffee (on one occasion) and with coffee (on another occasion). Capillary glucose was measured in the healthy subjects at 0, 15, 30, 45, 60, 90 and 120 min and for the diabetics at 0, 30, 60, 90, 120, 150 and 180 min. The glycemic indices were determined as ratios of the incremental areas under the response curves for the dates alone/with coffee compared to glucose. Statistical analyses were performed using Student's t-tests.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • required that those in the healthy group were healthy and in the diabetes group that their diabetes was controlled (HbA1c ≤8%) on diet with or without metformin

Exclusion Criteria:

  • morbid obesity (BMI > 40 kg/m2)
  • pre diabetes
  • pregnancy
  • presence of gastroenterological disorders
  • alimentary tract surgery
  • a history of gastroenteritis in the prior six months
  • any alcohol intake
  • smoking
  • taking any medications (except metformin)
  • poorly controlled diabetes (HbA1c > 8%) and the presence of acute or chronic diseases
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01422668

Locations
United Arab Emirates
Faculty of Medicine and Health Sciences UAE University
Al Ain, AB, United Arab Emirates
Sponsors and Collaborators
United Arab Emirates University
Investigators
Principal Investigator: Juma M Alkaabi, MD Assistant professor Internal Medicine Department FMHS UAE University
Study Chair: Bayan Al-Dabbag, PhD FMHS UAE university
Study Chair: Hussein Saadi, MD Professor of Medicine, FMHS UAE University
Study Chair: Salah Gariballa, MD Professor of Medicine FMHS UAE University
Study Chair: Yasin Javed, Msc FMHS UAE University
  More Information

No publications provided

Responsible Party: Juma Alkaabi, Assistant Professor of Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University
ClinicalTrials.gov Identifier: NCT01422668     History of Changes
Other Study ID Numbers: UAEU: GI Dates Study
Study First Received: August 18, 2011
Last Updated: August 23, 2011
Health Authority: United Arab Emirates: Al Ain Medical District Human Research Ethics Committee
United Arab Emirates: UAE University
United Arab Emirates: SEHA

Keywords provided by United Arab Emirates University:
Glycemic index
Dates
Diabetes
Coffee

Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on September 16, 2014