Alzheimer's Disease Core Center (ADCC)
The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening.
All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
Mild Cognitive Impairment
Age-Related Memory Disorders
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Arizona Alzheimer's Disease Core Center|
- Neuropsychological Test Scores [ Time Frame: Up to 20 years ] [ Designated as safety issue: No ]Cognitive function will be evaluated on a yearly basis using a battery of neuropsychological tests, which will then be scored and normed according to established guidelines.
- Neurological Exam [ Time Frame: Up to 20 Years ] [ Designated as safety issue: No ]A thorough neurological exam will be performed once per year to evaluate neurological function.
- Brain Tissue [ Time Frame: From date of entry until date of death assessed up to 20 years ] [ Designated as safety issue: No ]A brain autopsy will be performed upon the participant's death to establish histological diagnosis.
Biospecimen Retention: Samples With DNA
blood, saliva, brain tissue
|Study Start Date:||July 2001|
|Estimated Study Completion Date:||July 2025|
|Mild Cognitive Impairment|
|Other forms of Dementia, not AD|
|Normal Elderly Individuals|
All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
|United States, Arizona|
|University of Arizona, University Medical Center||Recruiting|
|Tucson, Arizona, United States, 85724|
|Contact: Kim Corley, B.A. 520-626-3746 firstname.lastname@example.org|
|Principal Investigator: Steven Z Rapcsak, M.D.|
|Principal Investigator:||Steven Z Rapcsak, M.D.||University of Arizona|