Alzheimer's Disease Core Center (ADCC)
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Purpose
The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening.
All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
| Condition |
|---|
|
Alzheimer's Disease Mild Cognitive Impairment Age-Related Memory Disorders |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Arizona Alzheimer's Disease Core Center |
- Neuropsychological Test Scores [ Time Frame: Up to 20 years ] [ Designated as safety issue: No ]Cognitive function will be evaluated on a yearly basis using a battery of neuropsychological tests, which will then be scored and normed according to established guidelines.
- Neurological Exam [ Time Frame: Up to 20 Years ] [ Designated as safety issue: No ]A thorough neurological exam will be performed once per year to evaluate neurological function.
- Brain Tissue [ Time Frame: From date of entry until date of death assessed up to 20 years ] [ Designated as safety issue: No ]A brain autopsy will be performed upon the participant's death to establish histological diagnosis.
Biospecimen Retention: Samples With DNA
blood, saliva, brain tissue
| Estimated Enrollment: | 900 |
| Study Start Date: | July 2001 |
| Estimated Study Completion Date: | July 2025 |
| Groups/Cohorts |
|---|
| Alzheimer's Disease |
| Mild Cognitive Impairment |
| Other forms of Dementia, not AD |
| Normal Elderly Individuals |
Detailed Description:
All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.
Eligibility| Ages Eligible for Study: | 50 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Individuals with Alzheimer's disease, mild cognitive impairment, other forms of dementia, and normal elderly individuals.
Inclusion Criteria:
For patients with MCI, or dementia, the presence of cognitive deficits including memory, language, and executive function.
Exclusion Criteria:
Presence of non-neurological medical conditions interfering with cognition.
Contacts and Locations| United States, Arizona | |
| University of Arizona, University Medical Center | Recruiting |
| Tucson, Arizona, United States, 85724 | |
| Contact: Kim Corley, B.A. 520-626-3746 kgcorley@email.arizona.edu | |
| Principal Investigator: Steven Z Rapcsak, M.D. | |
| Principal Investigator: | Steven Z Rapcsak, M.D. | University of Arizona |
More Information
No publications provided
| Responsible Party: | Steven Z Rapcsak, M.D., University of Arizona |
| ClinicalTrials.gov Identifier: | NCT01421420 History of Changes |
| Other Study ID Numbers: | P30AG19610, P30AG019610 |
| Study First Received: | July 25, 2011 |
| Last Updated: | August 19, 2011 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of Arizona:
|
Alzheimer's Dementia Mild Cognitive Impairment |
Additional relevant MeSH terms:
|
Alzheimer Disease Memory Disorders Cognition Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurodegenerative Diseases |
Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Dementia Tauopathies Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms |
ClinicalTrials.gov processed this record on June 18, 2013