Changes in the Permeability of the Blood Brain Barrier and Intestinal Barrier in Humans During Conditions of Stress and Immune Activation: in Vivo Studies

This study has been completed.
Information provided by:
National University Hospital, Singapore Identifier:
First received: August 15, 2011
Last updated: NA
Last verified: February 2009
History: No changes posted

The relevance of BBB and IB permeability changes as a major precipitating cause for cognitive and digestive dysfunction in the military stress setting.

Combat Training Stress

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Further study details as provided by National University Hospital, Singapore:

with combat training stress
without combat training stress


Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Male
Sampling Method:   Probability Sample
Study Population

Healthy male troops during combat training


Inclusion Criteria:

  • Healthy male troops (aged 18-50 yrs) scheduled to be engaged in a protracted multi-day stressful field exercises.

Exclusion Criteria:

  • Significantly systemic disease, including cardiovascular, psychiatric, neurological (including polyneuropathies) and endocrine disease including diabetes mellitus.
  • No written informed consent obtained from subject.
  Contacts and Locations
No Contacts or Locations Provided
  More Information

No publications provided Identifier: NCT01417416     History of Changes
Other Study ID Numbers: C/08/236, DSOCL08210
Study First Received: August 15, 2011
Last Updated: August 15, 2011
Health Authority: Singapore: Domain Specific Review Boards processed this record on April 17, 2014