Circulating Tumor Cells in Prostate Cancer Patients
The purpose of this study is to determine if a non-invasive cancer treatment, high-dose stereotactic body radiotherapy (SBRT), is associated with changes in circulating tumor cells counts in patients with low- and intermediate-risk prostate cancer.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Circulating Tumor Cells in Patients Undergoing Stereotactic Body Radiotherapy for Low- and Intermediate-Risk Prostate Cancer|
- To review the level of changes in circulating tumor cells with radiation. [ Time Frame: 2 weeks ] [ Designated as safety issue: No ]The investigator will review the coutns of circulating tumor cells (CTC). If there are significant changes in CTC levels with radiation, future studies will determine the prognostic significance of this information.
Biospecimen Retention: Samples Without DNA
|Study Start Date:||July 2011|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
|prostate cancer patients||
Other: Blood Drawing
Blood Drawing to measure circulating tumor cells counts.
Other Name: Blood Drawing for prostate cancer patients who undergo stereotactic body radiotherapy
SBRT (stereotactic body radiotherapy) may decrease or actually increase CTC levels in patients with cancer, and knowledge about the effects of different therapies, including SBRT, on CTC levels will be of general interest to the oncology community. Patients will undergo blood draws at defined times as indicated below.
- Prior to CT-simulation, but more than 2 days after digital rectal examination
- Within 24 hours following CT simulation (an endorectal balloon is used at the time of simulation)
- Within 24 hours following the first treatment
- Within 24 hours following the third treatment
- Within 1 week following the fifth treatment
Please refer to this study by its ClinicalTrials.gov identifier: NCT01414712
|United States, Texas|
|University of Texas Southwestern Medical Center|
|Dallas, Texas, United States, 75390|
|Principal Investigator:||Jeffrey Meyer, MD||University of Texas Southwestern Medical Center|