The Health Effect of Diet Rich in Nordic Berries (Berry)
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Purpose
Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures. The findings regarding the possible decrease of low-grade inflammation are existing also in humans. Low-grade inflammation has been suggested to be a mechanistic link between obesity and its consequences on cardiometabolic health. The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers.
| Condition | Intervention |
|---|---|
|
Metabolic Syndrome Impaired Glucose Tolerance Low-grade Inflammation Dyslipidemia |
Dietary Supplement: 300 g of strawberry, raspberry and cloudberry Dietary Supplement: 400 g of bilberry Other: Control diet |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Prevention |
| Official Title: | The Effect of Diet Rich in Nordic Berries on Gut Microbiota, Glucose and Lipid Metabolism and Metabolism on Fenolic Compounds |
- Glucose level [ Time Frame: week 8 ] [ Designated as safety issue: No ]Fasting glucose level oral glucose tolerance status at study week 8
- Cholesterol level [ Time Frame: week 8 ] [ Designated as safety issue: No ]total, HDL and LDL cholesterol level at the study week 8
- Inflammation markers [ Time Frame: week 8 ] [ Designated as safety issue: No ]Various inflammation markers were measured at the study week 8
- Markers of sterol metabolism [ Time Frame: week 8 ] [ Designated as safety issue: No ]Markers of cholesterol absorption and synthesis were measured
- gene expression in PBMCs [ Time Frame: study week 8 ] [ Designated as safety issue: No ]Global gene expression analyses in peripheral mononuclear cells (PBMC)
| Enrollment: | 56 |
| Study Start Date: | January 2006 |
| Study Completion Date: | March 2010 |
| Primary Completion Date: | December 2006 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: SRC
Strawberry, raspberry and cloudberry intervention for 8 weeks
|
Dietary Supplement: 300 g of strawberry, raspberry and cloudberry
100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted.
|
|
Experimental: BB
Bilberry intervention for 8 weeks
|
Dietary Supplement: 400 g of bilberry
Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set.
|
|
No Intervention: C
Control diet intervention with restrictions in berry consumption
|
Other: Control diet
Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks
|
Detailed Description:
Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.
The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.
Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.
Eligibility| Ages Eligible for Study: | 50 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- overweight (BMI 26-39 kg/m2), and two of the following:
- elevated fasting plasma glucose in the absence of diabetes (5.6-6.9 mmol/l)
- abnormal serum lipid concentration: fasting serum triglyceride concentration >1.7 mmol/L, fasting serum HDL cholesterol <1.0 mmol/L (males) or <1.3 mmol/L (females))
- waist circumference >102 cm (males) or >88 cm (females)
- blood pressure >130/85 mmHg
Exclusion Criteria:
- chronic diseases
- use of lipid lowering medication
Contacts and Locations| Finland | |
| University of Eastern Finland, Dpet of Public Health and Clinical Nutrition | |
| Kuopio, Finland, FIN-70211 | |
| Principal Investigator: | Riitta Törrönen, Adjunct Professor | University of Eastern Finland |
More Information
No publications provided by University of Eastern Finland
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Marjukka Kolehmainen, Senior scientist, University of Eastern Finland |
| ClinicalTrials.gov Identifier: | NCT01414647 History of Changes |
| Other Study ID Numbers: | 124//2005, 40361/05 |
| Study First Received: | August 10, 2011 |
| Last Updated: | April 16, 2012 |
| Health Authority: | Finland: Ethics Committee |
Keywords provided by University of Eastern Finland:
|
Bilberry Vaccinium myrtillus Metabolic syndrome Glucose metabolism |
Lipid metabolism Inflammation Gene expression |
Additional relevant MeSH terms:
|
Inflammation Dyslipidemias Glucose Intolerance Metabolic Syndrome X Pathologic Processes Lipid Metabolism Disorders |
Metabolic Diseases Hyperglycemia Glucose Metabolism Disorders Insulin Resistance Hyperinsulinism |
ClinicalTrials.gov processed this record on May 23, 2013