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Coenzyme Q10 and Vitamin A, C, E in Relation to the Oxidative Stress, Antioxidant Enzyme Activity and Inflammation in Subjects With Metabolic Syndrome

This study has been completed.
Sponsor:
Collaborator:
National Science Council, Taiwan
Information provided by:
Chung Shan Medical University
ClinicalTrials.gov Identifier:
NCT01412476
First received: August 8, 2011
Last updated: March 23, 2012
Last verified: March 2012
History of Changes
  Purpose

Metabolic syndrome (MS) is a significant risk factor of cardiovascular disease. However, the relationships between coenzyme Q10, antioxidant vitamins (Vitamin A, C, E) and the prevention of the risk of MS are still inconsistent. The purposes of this study are going to investigate the relation of coenzyme Q10, antioxidant vitamins concentration with the blood lipid levels, the markers of lipid peroxidation (TBARS), antioxidant enzymes activities (catalase, glutathione peroxidase and superoxide dismutase), and the inflammatory markers (hs-CRP,IL-6 and adiponectin). The investigators will recruit MS patients (case group, n = 100) and age-gender matched healthy subjects from previous study(n = 105) as a control group . The inclusion criteria of MS are according to the Bureau of Health Promotion, Department of Health in Taiwan (2007).Hopefully, the results of this study could provide the information to what has been know in MS subjects. The investigators expect coenzyme Q10 or antioxidant vitamins could be a preventive supplement to reduce the risk of MS.


Condition
Metabolic Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Chung Shan Medical University:

Biospecimen Retention:   Samples Without DNA

Blood samples


Enrollment: 72
Study Start Date: August 2010
Study Completion Date: March 2012
Groups/Cohorts
case group
Subjects with metabolic syndrome
control group
Healthy individuals

  Eligibility

Ages Eligible for Study:   20 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

The investigators recruited MS patients (case group, n = 100). The inclusion criteria of MS are according to the Bureau of Health Promotion, Department of Health in Taiwan (2007). The health subject were recrited from previous study (n = 105).

Criteria

Inclusion Criteria:

  • Metabolic syndrome
  • Healthy individuals with normal blood biochemical values.

Exclusion Criteria:

  • Age < 18y
  • Antioxidant vitamins supplements use
  • Pregnant women
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01412476

Locations
Taiwan
Ping-Ting Lin
Taichung, Taiwan
Sponsors and Collaborators
Chung Shan Medical University
National Science Council, Taiwan
Investigators
Principal Investigator: Ping-Ting Lin, Ph.D. Chung Shan Medical University
  More Information

No publications provided

Responsible Party: Ping-Ting Lin, Chung Shan Medical University
ClinicalTrials.gov Identifier: NCT01412476     History of Changes
Other Study ID Numbers: CS09155
Study First Received: August 8, 2011
Last Updated: March 23, 2012
Health Authority: Taiwan: Department of Health, Executive Yuan, R.O.C.

Additional relevant MeSH terms:
Metabolic Syndrome X
Insulin Resistance
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases

ClinicalTrials.gov processed this record on May 16, 2013