Effects of Monosodium Glutamate on Energy Balance and Eating Behavior
This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
|Official Title:||Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women|
- Change in body weight [ Time Frame: weeks 11, 12, and 25 ] [ Designated as safety issue: No ]Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.
- Change in body fat [ Time Frame: weeks 11 and 25 ] [ Designated as safety issue: No ]Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.
- Change in eating behavior [ Time Frame: weeks 11, 12 and 25 ] [ Designated as safety issue: No ]The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.
- Change in resting energy expenditure [ Time Frame: weeks 11, 12, and 25 ] [ Designated as safety issue: No ]The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.
|Study Start Date:||August 2011|
|Estimated Study Completion Date:||July 2014|
|Estimated Primary Completion Date:||July 2014 (Final data collection date for primary outcome measure)|
Placebo Comparator: Broth- NaCl
Sodium chloride containing broth matched for sodium content to the MSG broth
200 mL of sodium chloride containing broth, consumed three times per day
Active Comparator: Broth- MSG
MSG containing broth with the same sodium content as the placebo comparator.
200 mL of MSG containing broth consumed three times per day
The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.
|United States, California|
|Western Human Nutrition Center, University of California Davis|
|Davis, California, United States, 95616|
|Principal Investigator:||Kevin Laugero, PhD||WHNRC, ARS, University of California Davis|