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Effects of Monosodium Glutamate on Energy Balance and Eating Behavior

This study has been completed.
Sponsor:
Collaborator:
Ajinomoto USA, INC.
Information provided by (Responsible Party):
USDA, Western Human Nutrition Research Center
ClinicalTrials.gov Identifier:
NCT01410838
First received: August 3, 2011
Last updated: August 15, 2014
Last verified: August 2014
  Purpose

This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.


Condition Intervention
Obesity
Weight Gain
Food Preferences
Other: Broth

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women

Resource links provided by NLM:


Further study details as provided by USDA, Western Human Nutrition Research Center:

Primary Outcome Measures:
  • Change in body weight [ Time Frame: weeks 11, 12, and 25 ] [ Designated as safety issue: No ]
    Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.


Secondary Outcome Measures:
  • Change in body fat [ Time Frame: weeks 11 and 25 ] [ Designated as safety issue: No ]
    Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.

  • Change in eating behavior [ Time Frame: weeks 11, 12 and 25 ] [ Designated as safety issue: No ]
    The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.

  • Change in resting energy expenditure [ Time Frame: weeks 11, 12, and 25 ] [ Designated as safety issue: No ]
    The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.


Estimated Enrollment: 48
Study Start Date: August 2011
Study Completion Date: August 2014
Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: Broth- NaCl
Sodium chloride containing broth matched for sodium content to the MSG broth
Other: Broth
200 mL of sodium chloride containing broth, consumed three times per day
Active Comparator: Broth- MSG
MSG containing broth with the same sodium content as the placebo comparator.
Other: Broth
200 mL of MSG containing broth consumed three times per day

Detailed Description:

The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.

  Eligibility

Ages Eligible for Study:   19 Years to 50 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Women
  • Age 19-45
  • BMI 27-35
  • Blood pressure <140/90
  • Non-smoking

Exclusion Criteria:

  • Anemic: hgb < 11.5 mg/dL
  • Sensitivity to MSG (self reported)
  • Pregnant or planning to get pregnant
  • Taking medication for hypertension, depression, or weight loss
  • Diabetic
  • Vegetarian
  • MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia
  • blindness or heavily corrected vision
  • not fluent in English
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01410838

Locations
United States, California
Western Human Nutrition Center, University of California Davis
Davis, California, United States, 95616
Sponsors and Collaborators
USDA, Western Human Nutrition Research Center
Ajinomoto USA, INC.
Investigators
Principal Investigator: Kevin Laugero, PhD WHNRC, ARS, University of California Davis
  More Information

Additional Information:
No publications provided

Responsible Party: USDA, Western Human Nutrition Research Center
ClinicalTrials.gov Identifier: NCT01410838     History of Changes
Other Study ID Numbers: WHNRC 222718-2
Study First Received: August 3, 2011
Last Updated: August 15, 2014
Health Authority: United States: Federal Government

Keywords provided by USDA, Western Human Nutrition Research Center:
Obesity
Food preferences
Eating Behavior

Additional relevant MeSH terms:
Obesity
Weight Gain
Body Weight
Body Weight Changes
Nutrition Disorders
Overnutrition
Overweight
Signs and Symptoms

ClinicalTrials.gov processed this record on November 20, 2014