Effects of Monosodium Glutamate on Energy Balance and Eating Behavior
This study is currently recruiting participants.
Verified November 2012 by USDA, Western Human Nutrition Research Center
Sponsor:
USDA, Western Human Nutrition Research Center
Collaborator:
Ajinomoto USA, INC.
Information provided by (Responsible Party):
USDA, Western Human Nutrition Research Center
ClinicalTrials.gov Identifier:
NCT01410838
First received: August 3, 2011
Last updated: November 8, 2012
Last verified: November 2012
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Purpose
This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.
| Condition | Intervention |
|---|---|
|
Obesity Weight Gain Food Preferences |
Other: Broth |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Basic Science |
| Official Title: | Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women |
Resource links provided by NLM:
Further study details as provided by USDA, Western Human Nutrition Research Center:
Primary Outcome Measures:
- Change in body weight [ Time Frame: weeks 11, 12, and 25 ] [ Designated as safety issue: No ]Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.
Secondary Outcome Measures:
- Change in body fat [ Time Frame: weeks 11 and 25 ] [ Designated as safety issue: No ]Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss.
- Change in eating behavior [ Time Frame: weeks 11, 12 and 25 ] [ Designated as safety issue: No ]The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.
- Change in resting energy expenditure [ Time Frame: weeks 11, 12, and 25 ] [ Designated as safety issue: No ]The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system.
| Estimated Enrollment: | 48 |
| Study Start Date: | August 2011 |
| Estimated Study Completion Date: | July 2014 |
| Estimated Primary Completion Date: | July 2014 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Placebo Comparator: Broth- NaCl
Sodium chloride containing broth matched for sodium content to the MSG broth
|
Other: Broth
200 mL of sodium chloride containing broth, consumed three times per day
|
|
Active Comparator: Broth- MSG
MSG containing broth with the same sodium content as the placebo comparator.
|
Other: Broth
200 mL of MSG containing broth consumed three times per day
|
Detailed Description:
The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.
Eligibility| Ages Eligible for Study: | 19 Years to 45 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Women
- Age 19-45
- BMI 27-35
- Blood pressure <140/90
- Non-smoking
Exclusion Criteria:
- Anemic: hgb < 11.5 mg/dL
- Sensitivity to MSG (self reported)
- Pregnant or planning to get pregnant
- Taking medication for hypertension, depression, or weight loss
- Diabetic
- Vegetarian
- MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia
- blindness or heavily corrected vision
- not fluent in English
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01410838
Contacts
| Contact: Mary Ellen Rivera | (530) 754-5248 | maryellen.rivera@ars.usda.gov |
Locations
| United States, California | |
| Western Human Nutrition Center, University of California Davis | Recruiting |
| Davis, California, United States, 95616 | |
| Contact: Ellen Bonnel 530-752-4184 ellen.bonnel@ars.usda.gov | |
| Principal Investigator: Kevin Laugero | |
Sponsors and Collaborators
USDA, Western Human Nutrition Research Center
Ajinomoto USA, INC.
Investigators
| Principal Investigator: | Kevin Laugero, PhD | WHNRC, ARS, University of California Davis |
More Information
Additional Information:
No publications provided
| Responsible Party: | USDA, Western Human Nutrition Research Center |
| ClinicalTrials.gov Identifier: | NCT01410838 History of Changes |
| Other Study ID Numbers: | WHNRC 222718-2 |
| Study First Received: | August 3, 2011 |
| Last Updated: | November 8, 2012 |
| Health Authority: | United States: Federal Government |
Keywords provided by USDA, Western Human Nutrition Research Center:
|
Obesity Food preferences Eating Behavior |
Additional relevant MeSH terms:
|
Obesity Weight Gain Overnutrition Nutrition Disorders |
Overweight Body Weight Signs and Symptoms Body Weight Changes |
ClinicalTrials.gov processed this record on May 23, 2013