Study on the Effects of Exogenous Testosterone on Threat Perception and Behavioral Avoidance
The study aims to establish a clear causal link between testosterone and threat perception and behavioral responses to threat. Namely, the study focuses whether high levels of testosterone will cause an individual to exhibit increased physiological responses to threat (e.g., increased blood pressure, heart rate, and endocrine responses) and a decreased behavioral response (e.g., ignoring the threat, avoiding the threat, and postponing dealing with the threat). The threat in this study is a social threat involving public speaking, and is an outgrowth of previous research on the avoidance of health threats.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
|Official Title:||Study on the Effects of Exogenous Testosterone on Threat Perception and Behavioral Avoidance|
- Behavioral response [ Time Frame: 16 hours post testosterone administration ] [ Designated as safety issue: No ]Participants will be asked to give a public speech, but will be given the opportunity to postpone the speech to a future date. Postponement is considered an avoidance-oriented behavioral response to a perceived social threat.
- Physiological response [ Time Frame: 16 hours post testosterone administration ] [ Designated as safety issue: No ]Participants will have cortisol and cardiovascular tone tracked during the social threat protocol. Prior to, during, and after being asked, preparing, and giving a public speech, participants' physiological stress markers will be assessed.
|Study Start Date:||January 2012|
|Study Completion Date:||April 2012|
|Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
No Intervention: Placebo Control
Control group who will not receive exogenous testosterone administration. Will act as a comparison group to the testosterone group.
Experimental: Testosterone administration group
Experimental group that will receive a single 10 g dose of 1% testosterone topical gel.
Topical administration of testosterone gel. Participants receive a one-time, single dose of 10 g of 1% testosterone gel.
Other Name: AngroGel
Participants in the study will receive either a single dose of 10g 1% testosterone topical gel or placebo the day prior to participating in the study. The day of the study, participants will provide saliva samples throughout the study to track testosterone and cortisol levels. Participants will be asked to complete the Trier Social Stressor Task, which includes having to give a 5 minute speech to a panel of judges. Participants will be given the opportunity to postpone giving their speech to an unspecified date. The study will focus on two types of responses to the threat of public speaking: behavioral and physiological. The behavior of interest will be participants desire to postpone dealing with the threat (it is hypothesized that those in the testosterone administration group will have an increased desire to postpone). The physiological responses include increased levels of cortisol and increased cardiovascular tone (it is hypothesized that the testosterone administration group will show an increased physiological response compared to the placebo group).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01408498
|United States, Texas|
|Austin, Texas, United States, 78712|
|Principal Investigator:||Scott H Liening, B.A.||University of Texas at Austin|