Trial record 1 of 25 for:    "Typhoid fever"
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Understanding Typhoid Disease After Vaccination

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
Wellcome Trust
Imperial College London
University of Maryland
Information provided by (Responsible Party):
University of Oxford
ClinicalTrials.gov Identifier:
NCT01405521
First received: July 28, 2011
Last updated: August 12, 2013
Last verified: August 2013
  Purpose

Using an established model of human typhoid infection, whereby healthy adults are deliberately infected with typhoid-causing bacteria, the investigators will determine how effective a new oral typhoid vaccine (M01ZH09) is in preventing infection. A previously licensed oral typhoid vaccine (Ty21a) will be used to make sure the challenge model used works properly.


Condition Intervention Phase
Typhoid Fever
Enteric Fever
Typhoid
Biological: Vaccine placebo (excipients only)
Biological: Ty21a
Biological: M10ZH09 vaccine
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Understanding Typhoid Disease After Vaccination: a Single Centre, Randomised, Doubleblind, Placebo Controlled Study to Evaluate M01ZH09 in a Healthy Adult Challenge Model, Using Ty21a Vaccine as a Positive Control.

Resource links provided by NLM:


Further study details as provided by University of Oxford:

Primary Outcome Measures:
  • Diagnosis of typhoid fever [ Time Frame: 2 weeks after typhoid challenge ] [ Designated as safety issue: No ]

    Typhoid fever defined as development of Gram negative bacteraemia after day 5 or temperature over 38C persisting for 12 hours or more.

    Typhoid challenge defined as ingestion of virulent S. Typhi (Quailes strain).



Estimated Enrollment: 99
Study Start Date: December 2011
Estimated Study Completion Date: September 2014
Estimated Primary Completion Date: September 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: M01ZH09 vaccine Biological: M10ZH09 vaccine
single oral dose
Other Name: Typhella
Placebo Comparator: Vaccine placebo Biological: Vaccine placebo (excipients only)
single oral dose,
Ty21a vaccine
Positive control
Biological: Ty21a
3 oral doses, alternate days
Other Name: Vivotif

Detailed Description:

Typhoid is a serious infection killing up to 600,000 people every year; it is a frequent cause of fever and hospital admission in areas where disease is common. As the infection is restricted to humans, it should be possible to eliminate typhoid; better vaccines and ways of confirming infection are required in order for this to succeed. We propose to use a recently established human typhoid challenge model in order to evaluate a novel oral vaccine candidate and to develop new methods for diagnosing typhoid.

Although there are vaccines available to prevent typhoid, they offer little protection to populations where typhoid predominates, especially young children. Currently, the effectiveness of vaccines against typhoid cannot be predicted, as measures of protection against typhoid are unknown. As a result, implementation of vaccine programmes in disease endemic regions currently requires large and expensive trials in each new population, significantly delaying programmatic implementation.

We will use a typhoid challenge model to achieve our goal of accelerating the introduction of more effective vaccines into populations with a high burden of disease. Healthy adults will be vaccinated with either a novel oral typhoid vaccine or vaccine-placebo prior to being infected with the bacteria causing typhoid. This will allow us to measure the effectiveness of the vaccine and to identify components of the immune response important in producing protection against infection.

Current methods for confirming typhoid infection are slow and insensitive, particularly in endemic regions where the cost of laboratory equipment is prohibitive. In this project, we will also explore ways to diagnose typhoid, with the aim of developing tests that are quick, reliable and are be cost-effective in resource-poor settings. This would improve individual patient management, and allow accurate measurement of disease burden, which is vital to improve the efforts of vaccine programmes.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion criteria:

  • Male or female aged 18 - 60 years inclusive and in good health.
  • Have an abdominal ultrasound scan result documented demonstrating no evidence of gallbladder pathology.
  • Willing to allow their general practitioner and/or hospital consultant (if relevant) and the Health Protection Unit to be notified of participation in the study.
  • Agree to refrain from blood donation in the future if diagnosed with typhoid fever.
  • Be willing to have 24-hour contact with study staff during the four weeks post-challenge.

Exclusion Criteria:

  • Have previously received any typhoid vaccine, been resident in a typhoid endemic country for over 6 months, been diagnosed with probable or confirmed typhoid infection or been challenged with Salmonella Typhi or enrolled in a typhoid challenge study.
  • Have any known or suspected impairment or alteration of immune function.
  • History of significant cardiovascular disease.
  • History of significant respiratory disease.
  • History of significant endocrine disorder.
  • History of significant renal or bladder disease.
  • History of biliary tract disease.
  • History of significant gastrointestinal disease.
  • History of significant neurological disease.
  • History of significant metabolic disease.
  • History of significant haematological diagnosis.
  • History of psychiatric illness requiring hospitalisation, current known or suspected drug or alcohol misuse.
  • History of significant infectious disease.
  • History of non-benign cancer.
  • Presence of any implants or prostheses.
  • Hypersensitivity to any component of the vaccine or are hypersensitive to two or more of the following antibiotics: ciprofloxacin, azithromycin, ampicillin, trimethoprim sulfamethoxazole.
  • Female participant who is pregnant, lactating or who is unwilling to ensure that they or their partner use effective contraception one month prior to vaccination and continue to do so until two negative stool samples obtained a week apart, a minimum of 1 week after completion of antibiotic treatment have been obtained.
  • Current occupation involving: clinical or social work with direct contact with young children (defined as those attending pre-school groups, nursery or aged less than 2 years); highly susceptible patients or persons in whom typhoid infection would have particularly serious consequences (i.e. those who are immunocompromised or debilitated); care work involving the elderly.
  • Current occupation as a commercial food handler involving the preparation or serving of unwrapped foods not subjected to further heating.
  • Household contact with a young child (defined as above).
  • Household/close contact who is immunocompromised.
  • Scheduled elective surgery or other procedures requiring general anaesthesia during the vaccine/challenge period, at time of enrolment.
  • Participants who have taken part in other research involving an investigational product (IMP) within the 30 days prior to enrolment.
  • Have received blood, blood products and/or plasma derivatives including parenteral immunoglobulin preparations in the previous 3 months
  • Any other significant disease or disorder which, in the opinion of the investigator, may put the participants at risk because of participation in the study, may influence the result of the study, or affect the participant's ability to participate in the study.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01405521

Locations
United Kingdom
Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine
Oxford, United Kingdom
Sponsors and Collaborators
University of Oxford
Wellcome Trust
Imperial College London
University of Maryland
Investigators
Principal Investigator: Andrew J Pollard Oxford Vaccine Group, Department of Paediatrics, University of Oxford
  More Information

Additional Information:
No publications provided

Responsible Party: University of Oxford
ClinicalTrials.gov Identifier: NCT01405521     History of Changes
Other Study ID Numbers: OVG 2011/02, 2011-000381-35
Study First Received: July 28, 2011
Last Updated: August 12, 2013
Health Authority: United Kingdom: Medicines and Healthcare Products Regulatory Agency
United Kingdom: Research Ethics Committee

Keywords provided by University of Oxford:
typhoid vaccine M01ZH09
Ty21a typhoid vaccine

Additional relevant MeSH terms:
Fever
Typhoid Fever
Body Temperature Changes
Signs and Symptoms
Salmonella Infections
Enterobacteriaceae Infections
Gram-Negative Bacterial Infections
Bacterial Infections

ClinicalTrials.gov processed this record on April 17, 2014