NSAIDs in Coronary Artery Disease Patients
This study is currently recruiting participants.
Verified June 2012 by Heinrich-Heine University, Duesseldorf
Sponsor:
Heinrich-Heine University, Duesseldorf
Information provided by (Responsible Party):
Klinik für Kardiologie, Heinrich-Heine University, Duesseldorf
ClinicalTrials.gov Identifier:
NCT01402804
First received: July 25, 2011
Last updated: June 6, 2012
Last verified: June 2012
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Purpose
Introduction:
Different groups already showed in retrospective subgroup analyses, that there is an increased risk for cardiovascular events in patients on a simultaneous ASA/NSAID treatment.
Methods:
Light-Transmission aggregometry
Hypothesis:
Simultaneous administration of different NSAIDs and ASA impair the platelet inhibiting effect of ASA.
| Condition |
|---|
|
CAD |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Non-steroidal Anti-inflammatory Drugs Impair the Platelet Inhibiting Effect of Acetylsalicylic Acid in Coronary Artery Disease Patients |
Resource links provided by NLM:
Further study details as provided by Heinrich-Heine University, Duesseldorf:
| Estimated Enrollment: | 200 |
| Study Start Date: | July 2011 |
| Estimated Study Completion Date: | July 2014 |
| Estimated Primary Completion Date: | July 2013 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
| Stable CAD, ASA, NSAID |
| Stable CAD, ASA |
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
Patients with a stable CAD undergoing coronary angiography in the Universitätsklinik Düsseldorf.
Criteria
Inclusion Criteria:
- Patients on a simultaneous ASA, NSAID treatment
- > 18 years
Exclusion Criteria:
- unconsciousness, not able to consent
- reanimation, cardiac shock
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01402804
Contacts
| Contact: Amin Polzin, MD | 0211 81 ext 18800 | amin.polzin@med.uni-duesseldorf.de |
Locations
| Germany | |
| Heinrich-Heine-University | Recruiting |
| Düsseldorf, NRW, Germany, 40225 | |
| Contact: Amin Polzin, MD 0211 81 18800 amin.polzin@med.uni-duesseldorf.de | |
| Principal Investigator: Malte Kelm, MD | |
| Principal Investigator: Tobias Zeus, MD | |
| Principal Investigator: Thomas Hohlfeld, MD | |
| Principal Investigator: Amin Polzin, MD | |
Sponsors and Collaborators
Heinrich-Heine University, Duesseldorf
Investigators
| Principal Investigator: | Amin Polzin, MD | Klinik für Kariologie, Pneumologie und Angiologie, Universtiätsklinikum Düsseldorf |
| Study Chair: | Tobias Zeus, MD | Klinik für Kardiologie, Pneumologie und Angiologie |
| Study Chair: | Thomas Hohlfeld, MD | Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Univerität Düsseldorf |
| Study Director: | Malte Kelm, MD | Heinrich-Heine University, Duesseldorf |
More Information
Additional Information:
No publications provided
| Responsible Party: | Klinik für Kardiologie, Klinik für Kardiologie, Pneumologie und Angiologie, Heinrich-Heine University, Duesseldorf |
| ClinicalTrials.gov Identifier: | NCT01402804 History of Changes |
| Other Study ID Numbers: | AGP-0001 |
| Study First Received: | July 25, 2011 |
| Last Updated: | June 6, 2012 |
| Health Authority: | Germany: Ethics Commission |
Additional relevant MeSH terms:
|
Coronary Artery Disease Myocardial Ischemia Coronary Disease Heart Diseases Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Aspirin Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents |
Physiological Effects of Drugs Pharmacologic Actions Therapeutic Uses Antirheumatic Agents Fibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms of Pharmacological Action Cardiovascular Agents Hematologic Agents Platelet Aggregation Inhibitors Cyclooxygenase Inhibitors Enzyme Inhibitors Antipyretics Central Nervous System Agents |
ClinicalTrials.gov processed this record on May 22, 2013