Energy Expenditure and Body Composition in Pseudohypoparathyroidism 1a
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The investigators would like to learn more about the metabolic consequences of pseudohypoparathyroidism type 1a in children, adolescents and adults with this condition. People with pseudohypoparathyroidism 1a are at risk for development of obesity. To better understand the cause of overweight or obesity, investigators are measuring body composition and resting energy expenditure (REE), which is the amount of calories burned while completely at rest. The investigators also want to determine the amount of body fat.
| Condition |
|---|
|
Pseudohypoparathyroidism Type 1A Albright Hereditary Osteodystrophy |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Cross-Sectional |
| Official Title: | Altered Resting Energy Expenditure as a Cause of Obesity in Pseudohypoparathyroidism 1a: A Pilot Study |
- Resting Energy Expenditure [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]The subject will rest for 30 minutes in the lab prior to the start of the test. A 60-minute resting energy expenditure (REE) test will be performed between 7:00 and 10:00 A.M. with the subject resting quietly under a clear, plastic hood watching a videotape.
- Characterize body composition in patients with PHP1a. [ Time Frame: 12 months ] [ Designated as safety issue: No ]Body composition outcomes will be characterized by whole body lean mass and fat mass sex- and race-specific z-scores relative to height.
| Estimated Enrollment: | 20 |
| Study Start Date: | June 2011 |
| Estimated Study Completion Date: | December 2013 |
| Estimated Primary Completion Date: | August 2013 (Final data collection date for primary outcome measure) |
Pseudohypoparathyroidism 1a (PHP1a) is a disorder that is associated with many endocrine problems. People with PHP1a are at risk for the development of obesity. The objective of the study will help determine if obesity is related to abnormalities energy expenditure, meaning that people with PHP1a may not burn as many calories while at rest as those without the disorder.
In order to further evaluate obesity in PHP1a, investigators are planning to measure resting energy expenditure (REE), which is the amount of calories burned while completely at rest. Investigators will also evaluate body composition by looking at measures of growth and development and determining the amount of body fat using dual energy x-ray absorptiometry (DXA) as well as blood and urine biologic markers of obesity. The investigators plan to evaluate people with PHP1a at all weights.
Eligibility| Ages Eligible for Study: | 5 Years to 45 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Subjects with Pseudohypoparathyroidism 1a
Inclusion Criteria:
- Diagnosis of pseudohypoparathyroidism 1a
- Any body weight
Exclusion Criteria:
- Absence of above diagnosis
Contacts and Locations| Contact: Michael A Levine, MD | 215-590-3618 | levinem@chop.edu |
| United States, Pennsylvania | |
| Children's Hospital of Philadelphia | Recruiting |
| Philadelphia, Pennsylvania, United States, 19104 | |
| Principal Investigator: Michael A Levine, MD | |
| Principal Investigator: | Michael A Levine, M.D. | Children's Hospital of Philadelphia |
More Information
No publications provided
| Responsible Party: | Children's Hospital of Philadelphia |
| ClinicalTrials.gov Identifier: | NCT01398774 History of Changes |
| Other Study ID Numbers: | 11-007972 |
| Study First Received: | July 19, 2011 |
| Last Updated: | March 19, 2013 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Children's Hospital of Philadelphia:
|
Pseudohypoparathyroidism 1a Albright Hereditary Osteodystrophy |
Additional relevant MeSH terms:
|
Fibrous Dysplasia, Polyostotic Fibrous Dysplasia of Bone Pseudohypoparathyroidism Pseudopseudohypoparathyroidism Bone Diseases, Metabolic Bone Diseases Musculoskeletal Diseases |
Metal Metabolism, Inborn Errors Metabolism, Inborn Errors Genetic Diseases, Inborn Calcium Metabolism Disorders Metabolic Diseases Osteochondrodysplasias Bone Diseases, Developmental |
ClinicalTrials.gov processed this record on May 22, 2013