Comparison the Value of Several Biomarkers of Sepsis
The purpose of this study is to describe the value of serum sTREM (soluble triggering receptor expressed on myeloid cells)-1, sCD163, procalcitonin (PCT), C-reactive protein (CRP) concentrations, white blood cell (WBC) count and SOFA score during sepsis and their clinical informative value in predicting outcome.
Systemic Inflammatory Response Syndrome
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Comparison of the Value of Serum sTREM-1, sCD163, PCT, CRP Concentrations, WBC Count and SOFA Score During Sepsis and Their Clinical Informative Value in Predicting Outcome|
- Patients Outcome [ Time Frame: 28 days ] [ Designated as safety issue: No ]The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death
|Study Start Date:||September 2009|
|Study Completion Date:||July 2011|
|Primary Completion Date:||July 2011 (Final data collection date for primary outcome measure)|
(1) temperature > 38oC or < 36oC; (2) pulse rate > 90 beats/min; (3) ventilation rate > 20 breaths/min or hyperventilation with a partial pressure of arterial carbon dioxide (PaCO2) < 32 mmHg; (4) white blood cell (WBC) count >1 2,000μL-1 or < 4000 μL-1 , or > 10% immature cells.
SIRS + infection
The investigators enrolled 130 subjects admitted to an ICU: 30 cases with systemic inflammatory response syndrome (SIRS), 36 cases with sepsis, 35 cases with and 29 with septic shock. Results for sTREM (soluble triggering receptor expressed on myeloid cells)-1, sCD163, procalcitonin (PCT), C-reactive protein (CRP) concentrations, white blood cell (WBC) count and SOFA score were recorded on days 1, 3, 5, 7, 10, and 14.
|Chinese PLA General Hospital|
|Beijing, Beijing, China, 100853|
|Study Director:||Xie Lixin, Doctor||Department Of Respiratory Diseases, Chinese PLA General Hospital|