Comparison the Value of Several Biomarkers of Sepsis
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Purpose
The purpose of this study is to describe the value of serum sTREM (soluble triggering receptor expressed on myeloid cells)-1, sCD163, procalcitonin (PCT), C-reactive protein (CRP) concentrations, white blood cell (WBC) count and SOFA score during sepsis and their clinical informative value in predicting outcome.
| Condition |
|---|
|
Systemic Inflammatory Response Syndrome Sepsis |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Comparison of the Value of Serum sTREM-1, sCD163, PCT, CRP Concentrations, WBC Count and SOFA Score During Sepsis and Their Clinical Informative Value in Predicting Outcome |
- Patients Outcome [ Time Frame: 28 days ] [ Designated as safety issue: No ]The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death
| Enrollment: | 130 |
| Study Start Date: | September 2009 |
| Study Completion Date: | July 2011 |
| Primary Completion Date: | July 2011 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
SIRS
(1) temperature > 38oC or < 36oC; (2) pulse rate > 90 beats/min; (3) ventilation rate > 20 breaths/min or hyperventilation with a partial pressure of arterial carbon dioxide (PaCO2) < 32 mmHg; (4) white blood cell (WBC) count >1 2,000μL-1 or < 4000 μL-1 , or > 10% immature cells.
|
|
Sepsis
SIRS + infection
|
Detailed Description:
The investigators enrolled 130 subjects admitted to an ICU: 30 cases with systemic inflammatory response syndrome (SIRS), 36 cases with sepsis, 35 cases with and 29 with septic shock. Results for sTREM (soluble triggering receptor expressed on myeloid cells)-1, sCD163, procalcitonin (PCT), C-reactive protein (CRP) concentrations, white blood cell (WBC) count and SOFA score were recorded on days 1, 3, 5, 7, 10, and 14.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Between September 2009 and July 2011, inpatients were included who were in the intensive care units (ICU) of the Department of Respiratory Disease, the Emergency Department, and the Department of Surgery of the Chinese People's Liberation Army General Hospital.
Inclusion Criteria:
- Male and female aged 18 years old and over;
- Clinically suspected infection;
- Fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 °C or lower than 36 °C (b)respiratory rate above 20/min, or PCO2 below 32 mmHg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/μl or lower than < 4,000/μl or less than 10% of bands.
Exclusion Criteria:
- Those who fulfilled one below:
- neutropenia (≤ 500 neutrophils/mm3)
- HIV infection, and
- patients or their relatives refused
Contacts and Locations| China, Beijing | |
| Chinese PLA General Hospital | |
| Beijing, Beijing, China, 100853 | |
| Study Director: | Xie Lixin, Doctor | Department Of Respiratory Diseases, Chinese PLA General Hospital |
More Information
No publications provided
| Responsible Party: | Lixin Xie, Department Of Respiratory Diseases, Chinese PLA General Hospital |
| ClinicalTrials.gov Identifier: | NCT01388725 History of Changes |
| Other Study ID Numbers: | 20090923-001,20100701-002, 2009BAI86B03 |
| Study First Received: | July 5, 2011 |
| Last Updated: | July 6, 2011 |
| Health Authority: | China: Ethics Committee |
Keywords provided by Chinese PLA General Hospital:
|
sTREM-1 sCD163 PCT CRP WBC count |
SOFA score SIRS sepsis severity prognosis |
Additional relevant MeSH terms:
|
Sepsis Toxemia Systemic Inflammatory Response Syndrome Infection |
Inflammation Pathologic Processes Shock |
ClinicalTrials.gov processed this record on May 16, 2013