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The Detection and Factors of Brown Adipose Tissue in Different Locations of Adults

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2010 by Huashan Hospital.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Huashan Hospital
ClinicalTrials.gov Identifier:
NCT01387451
First received: June 30, 2011
Last updated: July 1, 2011
Last verified: April 2010
  Purpose

Retrospective studies have combined positron-emission tomography and computed tomography (PET-CT) to identify adipose tissue with a high rate of uptake of 18F-fluorodeoxyglucose(18F-FDG) as active brown adipose tissue(BAT). In addition, biopsy specimens and immunohistochemical staining with a UCP1-specific antiserum were used to indicate that normal adults were able to have BAT. However,these studies only chose few subjects and limited to the neck tissue. Therefore, the investigators intend to test BAT in different parts of adults and analyse the clinical factors.


Condition
Obesity

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Cross Sectional Study on the Detection and Factors of Brown Adipose Tissue in Different Locations of Adults

Further study details as provided by Huashan Hospital:

Biospecimen Retention:   Samples Without DNA

Adipose tissue, plasma


Estimated Enrollment: 30
Study Start Date: October 2010
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Detailed Description:

The investigators will promote the cross-sectional study from 2010 to 2013 in Shanghai. Data on demographic statistics, medical history,physical examination and fasting blood sample will be collected for all patients. Adipose tissue of adults will be collected from different regions, such as cervical, perirenal, along the large blood vessels and trachea, because they are included in the range of surgical therapy and are the major locations of BAT. Adipose tissue samples will be used to immunohistochemical stain, to detect the expression of BAT related genes.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Subjects who underwent surgical therapy from 2010 to 2013 in Huashan Hospital and the operation scope includes brown adipose tissue sample sites.

Criteria

Inclusion Criteria:

  • Subjects who underwent surgical therapy and the operation scope includes BAT sample sites.

Exclusion Criteria:

  • Pregnant women
  • With implantable medical electronic instrument
  • Younger than 18 years
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01387451

Locations
China, Shanghai
Huashan Hospital
Shanghai, Shanghai, China, 200040
Sponsors and Collaborators
Huashan Hospital
Investigators
Study Chair: Yiming Li, Doctor Huashan Hospital, Fudan University
  More Information

No publications provided

Responsible Party: Yiming Li, huashan Hospital
ClinicalTrials.gov Identifier: NCT01387451     History of Changes
Other Study ID Numbers: KY2010-115
Study First Received: June 30, 2011
Last Updated: July 1, 2011
Health Authority: China: Ethics Committee

Keywords provided by Huashan Hospital:
Brown adipose tissue
Different regions
Chinese adults

ClinicalTrials.gov processed this record on November 20, 2014