The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by:
Meir Medical Center
ClinicalTrials.gov Identifier:
NCT01384136
First received: June 27, 2011
Last updated: NA
Last verified: June 2011
History: No changes posted
  Purpose

The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.

The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes.

The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.


Condition
Telomere Length
Mechanisms of Telomter Homeostasis
High Risk Pregnancies

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

Further study details as provided by Meir Medical Center:

Estimated Enrollment: 100
Study Start Date: June 2011
Estimated Study Completion Date: June 2015
Estimated Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts
High risk pregnancy
|Control - Normal low risk pregnancies

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

High risk pregnancies, third trimester, after the delivery/

Criteria

Inclusion Criteria:

  • Third trimester post delivery
  • Intrauterine growth restriction
  • Preeclampsia
  • Diabetes
  • Control - low risk normal pregnancies

Exclusion Criteria:

  • Patients who do not want to participate
  • Known HIV or Hepatitis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01384136

Locations
Israel
Meir Medical Center
Kfar Saba, Israel
Sponsors and Collaborators
Meir Medical Center
  More Information

No publications provided

Responsible Party: Tal Biron-Shental, Meir Medical Center, Kfar Saba, Israel
ClinicalTrials.gov Identifier: NCT01384136     History of Changes
Other Study ID Numbers: 036-2011 MMC
Study First Received: June 27, 2011
Last Updated: June 27, 2011
Health Authority: Internal Review Board - Helsinki Committee,Meir Medical Center Kfar Saba, Israel':'
Israel: The Israel National Institute for Health Policy Research and Health Services Research

ClinicalTrials.gov processed this record on September 29, 2014