T-cell-immunity During Standard Radiotherapy in Localised Prostate Cancer
Immunological effects of radiotherapy have been described before, but not evaluated in a time-dependant manner.
In order to identify a possible time frame for combination therapies, white blood cells are isolated of samples taken at different time points before during and after standard radiotherapy in patients with localised prostate cancer. The overall activity of the T-cell-system as well as tumor-specific T-cell-response are evaluated.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Changes of T-cell-immune-status During Curative Radiotherapy in Prostate Cancer|
- T-cell-immunity in time-course [ Time Frame: During and 3-6 months after radiotherapy ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Peripheral blood mononuclear cells and serum are frozen and stored.
|Study Start Date:||March 2011|
|Department of Radiation Oncology|
|Tuebingen, Germany, D-72076|
|Principal Investigator:||Cihan Gani, M.D.||University Hospital Tuebingen|
|Study Director:||Franziska Eckert, MD||University Hospital Tuebingen|