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Influence Continuous Veno-venous Hemodialysis the Autoregulation (dARICUCVVH)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Patrick Schramm, Johannes Gutenberg University Mainz
ClinicalTrials.gov Identifier:
NCT01376531
First received: June 15, 2011
Last updated: April 12, 2013
Last verified: April 2013
History of Changes
  Purpose

The aim of the study is to characterize the influence of continuous veno-venous hemodialysis on the cerebrovascular autoregulation.


Condition Intervention
Acute Renal Failure
 Procedure: continuous veno-venous hemodialysis

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Influence of Continuous Veno-venous Hemodialysis on Cerebrovascular Autoregulation in Patients With Acute Renal Failure

Resource links provided by NLM:

MedlinePlus related topics: Dialysis
U.S. FDA Resources

Further study details as provided by Johannes Gutenberg University Mainz:

Primary Outcome Measures:
  • Change from Baseline cerebrovascular autoregulation to cerebrovascular autoregulation during continuous veno-venous hemodialysis [ Time Frame: 1 Year ] [ Designated as safety issue: No ]
    Is there an influence of continuous veno-venous hemodialysis at the cerebrovascular autoregulation, which would be a side effect with limiting use in patients with brain injury or the need of intensive monitoring of cerebral perfusion pressure in this patients.


Enrollment: 20
Study Start Date: January 2011
Study Completion Date: June 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
acute renal failure
patients at intensive care unit with definition of acute renal failure and the need for continuous veno-venous hemodialysis
 Procedure: continuous veno-venous hemodialysis
continuous veno-venous hemodialysis
Other Name: CVVHD

Detailed Description:

Patients at the intensive care unit who suffered acute renal failure with the need of continuous veno-venous hemodialysis will be investigated with continuous veno-venous hemodialysis and in a time window without continuous veno-venous hemodialysis to investigate the influence of continuous veno-venous hemodialysis on the cerebrovascular autoregulation.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients at ICU with acute renal failure and the need of continuos veno-venous hemodialysis

Criteria

Inclusion Criteria:

  • acute renal failure
  • need for continuous veno-venous hemodialysis
  • age >18 Years

Exclusion Criteria:

  • Sepsis
  • Preexisting cerebral illness
  • traumatic brain injury
  • Meningitis or encephalitis
  • Pregnancy
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01376531

Locations
Germany
University medical centre
Mainz, Germany, 55131
Sponsors and Collaborators
Johannes Gutenberg University Mainz
Investigators
Principal Investigator: Patrick Schramm, MD Department of Anesthesiology, University medicine Mainz, Germany
  More Information

Publications:

Responsible Party: Patrick Schramm, Senior Physician, Johannes Gutenberg University Mainz
ClinicalTrials.gov Identifier: NCT01376531     History of Changes
Other Study ID Numbers: 837.041.10 2
Study First Received: June 15, 2011
Last Updated: April 12, 2013
Health Authority: Germany: Ethics Commission

Keywords provided by Johannes Gutenberg University Mainz:
acute renal failure
cerebrovascular autoregulation
transcranial Doppler
continuous veno-venous hemodialysis

Additional relevant MeSH terms:
Acute Kidney Injury
Renal Insufficiency
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on May 23, 2013