71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women (17b-ACO)
An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies.
Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors, the investigators hypothesis is that women with PCOS and with the variant allele G have a poor response on hirsutism and on hormonal and metabolic variables after oral contraceptive pill (OCP) treatment for 6 months.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||17-hydroxysteroid Dehydrogenase Type 5 Gene Polymorphism (71A/G HSD17B5 SNP) and Effects of Oral Contraceptive Pill on Hirsutism, Androgens and Metabolic Profile in Non-obese PCOS Women: a Pilot Study|
- Changes at Ferriman- Gallwey score [ Time Frame: 6 months ] [ Designated as safety issue: No ]
- Changes at testosterone levels [ Time Frame: 6 months ] [ Designated as safety issue: No ]
- Changes in lipid profile [ Time Frame: 6 months ] [ Designated as safety issue: No ]
|Study Start Date:||January 2005|
|Study Completion Date:||December 2010|
|Primary Completion Date:||January 2008 (Final data collection date for primary outcome measure)|
Drug: oral contraceptive pill