Macronutrients and Gut Hormone Secretion

This study has been completed.
Information provided by (Responsible Party):
Bo Ahren, Lund University Identifier:
First received: May 31, 2011
Last updated: March 14, 2014
Last verified: March 2014

Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes. Individual macronutrients or a mixed meal will therefore be served and gut hormones are measured during the following 300 min.

Condition Intervention
Type 2 Diabetes
Other: Macronutrients

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: Open Label
Official Title: Effects of Macronutrients on Gut Hormone and Islet Hormone Secretion in Healthy Volunteers and Type 2 Diabetes

Resource links provided by NLM:

Further study details as provided by Lund University:

Primary Outcome Measures:
  • Release of gut hormones [ Time Frame: 300 min ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Insulin secretion [ Time Frame: 300 min ] [ Designated as safety issue: No ]

Estimated Enrollment: 36
Study Start Date: September 2011
Study Completion Date: September 2013
Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Type 2 diabetes
Administration of macronutrients in type 2 diabetes
Other: Macronutrients
Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal
Other Names:
  • Glucose
  • Protein mixture
  • Fat emulsion
  • Mixed meal
Experimental: Healthy volunteers
Administration of macronutrients in healthy volunteers
Other: Macronutrients
Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal
Other Names:
  • Glucose
  • Protein mixture
  • Fat emulsion
  • Mixed meal

Detailed Description:

In healthy volunteers and subjects with dietary regulated diabetes mellitus, glucose, protein mixture or fat emulsion will be served individually and on a separate occasions a mixed meal will be served. Samples will be taken during the following 300 min. Concentrations of the gut hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, insulin and glucagon will be determined.


Ages Eligible for Study:   35 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy status or type 2 diabetes with dietary regulation

Exclusion Criteria:

  • Liver disease
  • kidney disease
  • thyroid disease
  Contacts and Locations
Please refer to this study by its identifier: NCT01366794

Department of Clinical Sciences Lund, Lund University
Lund, Sweden, 221 84
Lund University
Lund, Sweden, 22184
Sponsors and Collaborators
Lund University
Principal Investigator: Bo Ahrén, PhD Lund University
  More Information

No publications provided

Responsible Party: Bo Ahren, Professor, Lund University Identifier: NCT01366794     History of Changes
Other Study ID Numbers: 005
Study First Received: May 31, 2011
Last Updated: March 14, 2014
Health Authority: Sweden: Medical Products Agency

Keywords provided by Lund University:
Gut hormones
Insulin secretion

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions processed this record on April 23, 2014