MI Mortality Risk and Between-hospital Risk Variation in the United Kingdom and Sweden
Recruitment status was Active, not recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The study aims to investigate the differences in survival trajectories and hospital variability in myocardial infarction (MI) mortality rates in the UK and Sweden.
| Condition |
|---|
|
Acute Myocardial Infarction |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Retrospective |
| Official Title: | Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden |
- 30-day mortality [ Time Frame: 30-day ] [ Designated as safety issue: No ]all-cause mortality at 30-day following hospitalization for acute Myocardial Infarction
- 1-year mortality [ Time Frame: 1 year ] [ Designated as safety issue: No ]all-cause mortality at 1-year following hospitalization for acute Myocardial Infarction
| Estimated Enrollment: | 370000 |
| Study Start Date: | March 2011 |
| Estimated Study Completion Date: | December 2012 |
| Estimated Primary Completion Date: | June 2012 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
MINAP cohort
The Myocardial Ischaemia National Audit Project (MINAP) was established in 1999, in response to the national service framework (NSF) for coronary heart disease, to examine the quality of management of heart attacks (myocardial infarction) in hospitals in England and Wales.
|
|
RIKS-HIA cohort
The Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA) has been established to record clinical and treatment information for all patients admitted to the coronary care units in Sweden from 1995.
|
Detailed Description:
Limited evidence is available in comparing hospital level care and reference mortality risks between countries, due to the scarce availability of nationwide coronary heart disease data. The demographics and medical expenditure percentage are comparable in the United Kingdom and Sweden; however, the in-hospital case-fatality rates within 30 days after admission for acute myocardial infarction was greater in the UK than Sweden (6.3% versus 2.9%)(OECD, 2009). To investigate the discrepancy, the current study aims to compare the mortality risk differences and associated explanatory factors between the two countries. Results of the study can contribute to myocardial infarction care implementation in the UK and Sweden.
The UK Myocardial Ischaemia National Audit Project (MINAP)and Register of Information and Knowledge about Swedish Heart Intensive care Admissions (RIKS-HIA) are few quality national registries currently available for acute coronary syndrome. Using data from the MINAP and RIKS-HIA, we propose to investigate (1)the survival trajectories for a reference patient with myocardial infarction and (2) hospital variability in myocardial infarction mortality rate in the UK and Sweden, adjusted for important patient-level and hospital-level covariates.
Eligibility| Ages Eligible for Study: | 30 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
For the UK, all patients with an admission recorded in the MINAP database during 1st January 2004 and 31 December 2008 in 253 hospitals in England and Wales will be included in the study. For Sweden, all patients with an admission recorded in the RIKS-HIA during 1st January 2004 and 31 December 2008 in 74 hospitals in Sweden will be included. Only patients with acute myocardial infarction will be included as the study population.
Inclusion Criteria:
- Patients aged above 30 years old who had hospital admission for acute myocardial infarction.
- Admission period ranged from 1st January, 2004 to 31th December, 2008.
Exclusion Criteria:
- Patients with missing data in the admission time and/or primary outcomes.
Contacts and Locations| Sweden | |
| Uppsala Clinial Research Center | |
| Uppsala, Sweden, SE-751 85 | |
| United Kingdom | |
| University College London | |
| London, United Kingdom | |
| Principal Investigator: | Sheng-Chia Chung, Ph.D | University College, London |
More Information
Additional Information:
Publications:
| Responsible Party: | Sheng-Chia Chung, University College London |
| ClinicalTrials.gov Identifier: | NCT01359033 History of Changes |
| Other Study ID Numbers: | FP7-EIS-WP7-MINAP |
| Study First Received: | May 23, 2011 |
| Last Updated: | June 10, 2011 |
| Health Authority: | United Kingdom: the Myocardial Ischaemia National Audit Project Academic Group |
Keywords provided by University College, London:
|
Myocardial Infarction UK Sweden |
National audit registry MINAP RIKS-HIA |
Additional relevant MeSH terms:
|
Infarction Myocardial Infarction Ischemia Pathologic Processes Necrosis |
Myocardial Ischemia Heart Diseases Cardiovascular Diseases Vascular Diseases |
ClinicalTrials.gov processed this record on May 19, 2013