Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2010 by University of Oslo
Sponsor:
Collaborator:
Oslo University Hospital
Information provided by:
University of Oslo
ClinicalTrials.gov Identifier:
NCT01358630
First received: May 19, 2011
Last updated: May 23, 2011
Last verified: November 2010
  Purpose

The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.


Condition
Periodontitis
Vascular Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Periodontal-, Cardiovascular- and Aneurysmal Diseases.

Resource links provided by NLM:


Further study details as provided by University of Oslo:

Biospecimen Retention:   Samples With DNA

Whole blood, samples from vascular tissues (atherosclerotic plaques and aneurysmal wall), saliva


Estimated Enrollment: 100
Study Start Date: October 2008
Estimated Study Completion Date: October 2015
Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis, and randomly selected blood donors at Oslo University Hospital, Ullevål.

Criteria

Inclusion Criteria:

  • Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,

Exclusion Criteria:

  • patients whom undergone antibiotic treatment the past month.
  • patients whom undergone periodontal treatment the past 6 months.
  • patients with no teeth
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01358630

Contacts
Contact: Ingar Olsen, Prof.PhD. +47-22840350 ingar.olsen@odont.uio.no
Contact: Jørgen J Jørgensen, Prof.PhD +47-22894496 j.j.jorgensen@medisin.uio.no

Locations
Norway
Dental and Medical Faculty, University of Oslo Recruiting
Oslo, Norway, 0316
Contact: Ingar Olsen, Prof.PhD    47 22 84 03 50    ingaro@odont.uio.no   
Contact: Jørgensen J Jørgensen, Prof.PhD    47 22 89 44 96    j.j.jorgensen@medisin.uio.no   
Sponsors and Collaborators
University of Oslo
Oslo University Hospital
  More Information

No publications provided

Responsible Party: Professor, Ph.D., Dr.Odont Ingar Olsen/Professor PhD.MD. Jørgen J. Jørgensen, Institute of Oral Biology, Dental Faculty, University of Oslo/Oslo University Hospital, Departemnt of vascular surgery
ClinicalTrials.gov Identifier: NCT01358630     History of Changes
Other Study ID Numbers: 08/322b
Study First Received: May 19, 2011
Last Updated: May 23, 2011
Health Authority: Norway: Regional Ethics Commitee

Keywords provided by University of Oslo:
Periodontitis
Vascular disease
Proinflammatory cytokines

Additional relevant MeSH terms:
Vascular Diseases
Periodontitis
Cardiovascular Diseases
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases

ClinicalTrials.gov processed this record on September 18, 2014