Heart Rate Changes With Propofol

This study has been completed.
Information provided by (Responsible Party):
Christopher Lancaster, Nationwide Children's Hospital
ClinicalTrials.gov Identifier:
First received: May 17, 2011
Last updated: May 1, 2012
Last verified: May 2012

This is a prospective pilot study to quantify the changes in heart rate when propofol is administered after inhalational anesthesia induction.

Condition Intervention
Surgical Patients
Other: Observation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Changes in Heart Rate Following Administration of Propofol After Inhalational Induction

Resource links provided by NLM:

Further study details as provided by Nationwide Children's Hospital:

Primary Outcome Measures:
  • Change in heart rate [ Time Frame: Baseline & every 30 secs for 3 mins ] [ Designated as safety issue: No ]

Enrollment: 40
Study Start Date: May 2011
Study Completion Date: May 2012
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Propofol Other: Observation
There is no intervention, this is an observational study.


Ages Eligible for Study:   1 Year and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Surgery patients at Nationwide Children's Hospital.


Inclusion Criteria:

  1. At least 1 year of age or older.
  2. Routine (elective) surgical patients with ASA classifications of 1 or 2 (healthy).
  3. Patients that are already scheduled to receive inhalational induction followed by IV propofol.

Exclusion Criteria:

1. Premature infants of less than 30 weeks, who are less that 60 weeks post-gestational age at the time of study.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01355432

United States, Ohio
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Sponsors and Collaborators
Nationwide Children's Hospital
Principal Investigator: Christopher Lancaster, MD Nationwide Children's Hospital
  More Information

No publications provided

Responsible Party: Christopher Lancaster, Attending Anesthesiologist, Nationwide Children's Hospital
ClinicalTrials.gov Identifier: NCT01355432     History of Changes
Other Study ID Numbers: IRB11-00236
Study First Received: May 17, 2011
Last Updated: May 1, 2012
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Anesthetics, Intravenous
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Hypnotics and Sedatives

ClinicalTrials.gov processed this record on April 17, 2014