A Dose Titration of Droxidopa in Patients With Spinal Cord Injury

This study has been completed.
Sponsor:
Collaborator:
Chelsea Therapeutics
Information provided by:
Bronx VA Medical Center
ClinicalTrials.gov Identifier:
NCT01354158
First received: May 12, 2011
Last updated: July 29, 2013
Last verified: May 2011
  Purpose

The investigators seek to determine the efficacy, duration of action and safety of escalating dose of droxidopa on systemic blood pressure, cerebral blood flow and vasoactive hormones and catecholamines during upright seated posture.

Primary Question:

1. What is the lowest dose of droxidopa that increases seated SBP to 115±5 mmHg in men and 105±5 mmHg in women?

  • When does the defined increase in SBP occur after oral ingestion of droxidopa?
  • How long does this dose of droxidopa sustain SBP at these levels?
  • What are the vital signs and the subjective symptomology following droxidopa administration?

Secondary Question:

1. What is the MFV response to droxidopa administration in hypotensive individuals with SCI?

  • Does an increase in SBP correspond to an increase in MCA MFV?

Tertiary Question:

1. What is the vasoactive hormone and catecholamine response to droxidopa administration in hypotensive individuals with SCI?

  • Does droxidopa administration result in a change in APR, Aldo or NE in hypotensive individuals with SCI?

Condition Intervention Phase
Spinal Cord Injury
Hypotension
Drug: Droxidopa
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Dose Response Trial of Droxidopa to Treat Hypotension in Persons With SCI

Resource links provided by NLM:


Further study details as provided by Bronx VA Medical Center:

Primary Outcome Measures:
  • The lowest dose of droxidopa that increases seated SBP to 115±5 mmHg in men and 105±5 mmHg in women [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
    4 day titration of Droxidopa (placebo day 1, 100mg day 2, 200mg day 3, 400mg day). Blood pressure will be collected at the arm and finger (photoplethysmography) in 15 minute intervals during the duration of the protocol (approximately six hours). The subject will also wear a 24 hour portable arm blood pressure cuff, to assess the effect of Droxidopa on blood pressure 24 hrs post intervention.


Secondary Outcome Measures:
  • The MFV response to droxidopa administration in hypotensive individuals with SCI [ Time Frame: 4 days ] [ Designated as safety issue: No ]
    MFV will be measured each day at distinct time points to track cerebral blood flow during Droxidopa administration.

  • To assess the vasoactive hormone and catecholamine response to droxidopa administration in hypotensive individuals with SCI [ Time Frame: 4 days ] [ Designated as safety issue: No ]
    The catecholamine response to Droxidopa will be measured a total of 6 times throughout each study day by antecubital venipuncture.


Enrollment: 11
Study Start Date: May 2011
Study Completion Date: May 2013
Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Droxidopa
The dose-titration response to ascending doses of Droxidopa (placebo, 100mg, 200mg, 400mg) will be measured four separate days.
Drug: Droxidopa
Dose titration of placebo, 100mg, 200mg, 400mg of Droxidopa will be given to assess the effects of Droxidopa on blood pressure and cerebral blood flow.
Other Name: L-DOPs

Detailed Description:

Persons with spinal cord injury (SCI), due to partial to complete interruption of sympathetic pathways from the brainstem to the cardiovascular system are prone to blood pressure dysregulation including hypotension which is worsened during orthostasis. It is well established that orthostatic hypotension (OH) hinders the rehabilitation process during the acute phase of SCI but also may hamper the resumption of independence and activity in persons with chronic SCI. Surprisingly, only a few reports exist on the use and efficacy of an alpha receptor agonist (midodrine hydrochloride) to restore blood pressure to more normal levels in persons with tetraplegia. Our group has recently reported normalization of supine blood pressure with a relatively low dose of the nitric oxide synthase inhibitor (NOSi), nitro-L-arginine methyl ester (L-NAME). In addition to an alpha agonist and a NOSi, the use of a norepinephrine (NE) precursor, droxidopa, may be safe and efficacious for the treatment of orthostatic hypotension in a human model of SCI.

It has been demonstrated that the blood pressure-raising effect of 3,4-threo-dihydroxyphenylserine (droxidopa) occurs independently of the central nervous system in human models of neurologic OH by conversion to norepinephrine (NE) in neuronal and non-neuronal tissue. Oral droxidopa is taken up by the more peripheral sympathetic neurons, converted to NE, stored and released appropriately during postural stress. Droxidopa has been used for the effective treatment of OH in several human models of neurologically caused autonomic disorders, such as familial amyloid polyneuropathy, autoimmune autonomic neuropathy, pure autonomic failure, and multiple system atrophy . The effectiveness of droxidopa at improving orthostatic blood pressure in persons with SCI has not been studied. To date, only a single case on the use of the drug in a person with SCI has been reported and the use droxidopa in that case was successful. The purpose of this proposal is to determine the dose effectiveness, duration of action and any adverse events following droxidopa administration in hypotensive individuals with SCI.

To determine the efficacy, duration of action and safety of escalating dose of droxidopa on systemic blood pressure, cerebral blood flow and vasoactive hormones and catecholamines during upright seated posture.

Primary Question:

1. What is the lowest dose of droxidopa that increases seated SBP to 115±5 mmHg in men and 105±5 mmHg in women?

  • When does the defined increase in SBP occur after oral ingestion of droxidopa?
  • How long does this dose of droxidopa sustain SBP at these levels?
  • What are the vital signs and the subjective symptomology following droxidopa administration?

Secondary Question:

1. What is the MFV response to droxidopa administration in hypotensive individuals with SCI?

  • Does an increase in SBP correspond to an increase in MCA MFV?

Tertiary Question:

1. What is the vasoactive hormone and catecholamine response to droxidopa administration in hypotensive individuals with SCI?

  • Does droxidopa administration result in a change in APR, Aldo or NE in hypotensive individuals with SCI?
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • between the ages of 18 and 65,
  • diagnosed with hypotension as defined above,
  • able to provide informed consent

Exclusion Criteria:

  • Known or suspected sensitivity to study medication or any of its ingredients,
  • current smoker,
  • known coronary heart and/or artery disease,
  • hypertension,
  • diabetes mellitus or insipidus,
  • thyroid disease,
  • closed angle glaucoma,
  • acute illness,
  • major surgery in the last 30 days,
  • renal diseases,
  • pregnancy,
  • recent history (within the past year) of cocaine use,
  • tricyclic antidepressants, monoamine oxidase inhibitors, and catechol-O-methyltransferase inhibitors,
  • currently taking vasoconstricting medicines, such as Midodrine, ephedrine, dihydroergotamine, and the triptan class of migraine drugs,
  • Use of a halogen based anesthetic such as Halothane in the past 12 hours
  • Currently taking Isoproterenol and other catecholamine preparations
  • Peripheral Arterial Disease,
  • Abdominal Aortic Aneurysm,
  • Cerebrovascular Disease (Including prior CVA or TIA),
  • History of or active Congestive Heart Failure,
  • Known Systolic Dysfunction
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01354158

Locations
United States, New York
James J. Peters VA Medical Center
Bronx, New York, United States, 10468
Sponsors and Collaborators
Bronx VA Medical Center
Chelsea Therapeutics
Investigators
Principal Investigator: Jill M Wecht, EdD James J. Peters VA Medical Center
  More Information

No publications provided

Responsible Party: Jill M. Wecht/Health Science Specialist, James J. Peters VA Medical Center
ClinicalTrials.gov Identifier: NCT01354158     History of Changes
Other Study ID Numbers: 01272
Study First Received: May 12, 2011
Last Updated: July 29, 2013
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Hypotension
Spinal Cord Injuries
Wounds and Injuries
Vascular Diseases
Cardiovascular Diseases
Spinal Cord Diseases
Central Nervous System Diseases
Nervous System Diseases
Trauma, Nervous System
Droxidopa
Antiparkinson Agents
Anti-Dyskinesia Agents
Central Nervous System Agents
Therapeutic Uses
Pharmacologic Actions

ClinicalTrials.gov processed this record on April 16, 2014