The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma (CHI3L1)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2011 by China Medical University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01348932
First received: May 4, 2011
Last updated: May 5, 2011
Last verified: May 2011
  Purpose

The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma.


Condition
Asthma

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma

Resource links provided by NLM:


Further study details as provided by China Medical University Hospital:

Biospecimen Retention:   Samples With DNA

The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma. The association between CHI3L1 SNPs and the continuous outcomes were examined by real time PCR and gene sequencing analysis.


Estimated Enrollment: 1
Study Start Date: May 2011
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
Asthma
The relationship between single nucleotide polymorphisms of chitinase 3-like 1 gene, YKL-40 serum levels and adult asthma

Detailed Description:

Chitinase 3-like 1 (CHI3L1) is a member of human chitinases family. According to previous studies in literatures, increased expression of CHI3L1 has been proven to be correlated with the presence of different diseases, including cancers, autoimmune diseases, and chronic inflammatory conditions. Elevated serum levels of YKL-40 are associated with increased disease severity, poorer prognosis and shorter survival for many other diseases. When monitored over time, increases in serum YKL-40 parallel with disease progression. It can serve as an measurable marker of changes in disease status.

There were indicated that chitinase 3-like 1 might be associated with some clinical diseases. The C-allele of the -131 C→G (rs4950928) polymorphism of CHI3L1 has been shown to associate with bronchial hyperresponsiveness and reduced lung function. It is suggesting that variations in CHI3L1 may influence risk of asthma.

The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma. The association between CHI3L1 SNPs and the continuous outcomes were examined by real time PCR and gene sequencing analysis.

In Korean reports there was no significant associations between CHI3L1 SNPs and asthma were observed. On the other hand, there were association between CHI3L1 and asthma observed in the majority of Caucasian populations. However, similar research has not been conducted in Taiwan. In contrast to preliminary studies, the investigators predict the rs4950928 G allele, and not the C allele, was found to be associated with asthma. The g.-247C/T polymorphism in the CHI3L1 promoter region is associated with the risk of atopy.

  Eligibility

Ages Eligible for Study:   20 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Taiwan

Criteria

Inclusion Criteria:

  • ages 20 to 60 years
  • asthma patients
  • atopy patients
  • control (non-asthma and non-atopy)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01348932

Contacts
Contact: Chen Chia Hung, doctor 0975680802 hsnu758@gmail.com

Locations
Taiwan
China Medical University Hospital Recruiting
2 Yuh-Der Road, Taichung, Taiwan, 40447
Contact: Chen Chia Hung, doctor    0975680802    hsnu758@gmail.com   
Sponsors and Collaborators
China Medical University Hospital
Investigators
Study Director: Chen Chia Hung, doctor Partners
  More Information

No publications provided

Responsible Party: Chen Chia-Hung, China Medical University Hospital
ClinicalTrials.gov Identifier: NCT01348932     History of Changes
Other Study ID Numbers: DMR100-IRB-008
Study First Received: May 4, 2011
Last Updated: May 5, 2011
Health Authority: Taiwan: Department of Health

Keywords provided by China Medical University Hospital:
asthma
Chitinase 3-like 1 (CHI3L1)
YKL-40
single nucleotide polymorphism(SNP)
Real time PCR
gene

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on September 30, 2014