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The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

This study has been completed.
Sponsor:
Information provided by:
Frederiksberg University Hospital
ClinicalTrials.gov Identifier:
NCT01346995
First received: May 2, 2011
Last updated: May 3, 2011
Last verified: February 2010
History of Changes
  Purpose

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.


Condition Intervention
Muscle Strength
 Other: Experimental knee pain
Other: Non-painful control injections

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Frederiksberg University Hospital:

Primary Outcome Measures:
  • Isokinetic knee muscle strength [ Time Frame: At baseline and after 8 weeks of exercise ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • One-leg chair rise [ Time Frame: At baseline and after 8 weeks of exercise ] [ Designated as safety issue: No ]

Enrollment: 36
Study Start Date: February 2010
Study Completion Date: August 2010
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Experimental Knee Pain
Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad
 Other: Experimental knee pain
Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad
Active Comparator: Control
non-painful injections of isotonic saline into the infrapatellar fatpad.
 Other: Non-painful control injections
Injection of isotonic saline into the infrapatellar fat pad

  Eligibility

Ages Eligible for Study:   20 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • aged between 20 to 35 years
  • healthy
  • untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion Criteria:

  • symptomatic musculoskeletal diseases
  • history of traumatic injuries to muscles, tendons or joints of the lower extremity
  • knee joint pain within a month prior to enrollment
  Contacts and Locations
No Contacts or Locations Provided
  More Information

No publications provided by Frederiksberg University Hospital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Henning Bliddal, The Parker Institute
ClinicalTrials.gov Identifier: NCT01346995     History of Changes
Other Study ID Numbers: 072.07
Study First Received: May 2, 2011
Last Updated: May 3, 2011
Health Authority: Denmark: The Capital Region of Denmark

ClinicalTrials.gov processed this record on May 23, 2013