Subclassification of the Syndrome of Inappropriate ADH Secretion

This study has been completed.
Sponsor:
Information provided by:
University of Wuerzburg
ClinicalTrials.gov Identifier:
NCT01341665
First received: April 21, 2011
Last updated: April 25, 2011
Last verified: April 2011
  Purpose

The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH.

These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.


Condition
Hyponatremia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH?

Further study details as provided by University of Wuerzburg:

Estimated Enrollment: 50
Study Start Date: March 2008
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

patients with chronic hyponatremia (> 3 days) due to SIADH in university hospital in wuerzburg

healthy control subjects with normonatremia

Criteria

Inclusion Criteria:

  • age > 18 years,
  • hyponatremia < 132 mmol/L
  • SIADH

Exclusion Criteria:

  • age < 18 years
  • cerebral metastases
  • serum sodium > 132mmol/L
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01341665

Locations
Germany
University of Wuerzburg
Wuerzburg, Bavaria, Germany, 97080
Sponsors and Collaborators
University of Wuerzburg
Investigators
Study Chair: Bruno Allolio, MD Ethical commitee
  More Information

No publications provided

Responsible Party: Prof. Dr. Bruno Allolio, Department of Endocrinology and Diabetes, University of Wuerzburg
ClinicalTrials.gov Identifier: NCT01341665     History of Changes
Other Study ID Numbers: 5/08
Study First Received: April 21, 2011
Last Updated: April 25, 2011
Health Authority: Germany: Ethics Commission

Keywords provided by University of Wuerzburg:
hyponatremia
SIADH
copeptin

Additional relevant MeSH terms:
Hyponatremia
Inappropriate ADH Syndrome
Brain Diseases
Central Nervous System Diseases
Endocrine System Diseases
Hypothalamic Diseases
Metabolic Diseases
Nervous System Diseases
Pituitary Diseases
Water-Electrolyte Imbalance

ClinicalTrials.gov processed this record on October 29, 2014