Relevance of Biomarkers in the Process of Weaning
Recruitment status was Recruiting
The purpose of the study is to examine the relevance of biochemical markers (specific pulmonary and cardiac markers and markers of endogenous stress) in the process of weaning in patients with artificial ventilation.
Duration of Weaning
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Relevance of Biochemical Markers in the Process of Weaning|
- success of weaning [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 30days ] [ Designated as safety issue: No ]primary outcome measure is the success of weaning during hospital stay. Duration of hospital stay is estimated between 1-60days, in average 30days. Criteria is spontaneous breathing.
- follow up [ Time Frame: 12 months ] [ Designated as safety issue: No ]Follow up is done after 12 months to check major adverse cardiac or pulmonary events (death, myocardial infarction, re-hospitalisation)
Biospecimen Retention: Samples With DNA
routine blood parameters
|Study Start Date:||April 2011|
|Estimated Study Completion Date:||April 2013|
|Estimated Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
Artificially ventilated patients on our intensive care unit will be monitored if specific biomarkers have a relevance in risk stratification, optimizing therapy, outcome and success in the process of weaning. Therefore, consecutively, specific blood parameters will be taken at time of intubation,day 1 of weaning and extubation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01341561
|Contact: Evangelos Giannitsis, Prof. Dr.||0049-6221-56-38686||Evangelos_Giannitsis@med.uni-heidelberg.de|
|Intensive Care Unit, University of Heidelberg||Recruiting|
|Heidelberg, Baden-Württemberg, Germany, 69120|
|Contact: Evangelos Giannitsis, Prof. Dr. 004962215638686 Evangelos_Giannitsis@med.uni-heidelberg.de|