Psychometric Validation of Cognitive Endpoints

Individuals with Multiple Sclerosis

Inclusion Criteria:

• 18 to 65 years old (inclusive).
• History of Relapsing-Remitting or Secondary Progressive Multiple Sclerosis
• Physically able to see the testing materials and complete the tests
• Have a family member or caregiver who is capable of consent and willing to complete the MSNQ-Informant questionnaire.

Exclusion Criteria:

• A history of treated or untreated severe mental illness or diagnosis of major depression prior to MS onset.
• Untreated major depression or untreated anxiety disorder.
• History of Attention Deficit/Hyperactivity Disorder, Developmental Learning - Disorder including Mental Retardation.
• History of traumatic brain injury with intracranial bleed, stroke, Alzheimer's disease, Parkinson's disease, Motor Coordination Disorder or other neurologic illness. I understand that if the Investigator believes this would interfere with successful completion of the protocol, I will be excluded.
• A clinically significant relapse within the past 2 months. I have had a serious infection (e.g., pneumonia, septicemia) within the 2 month.
• History of drug or alcohol abuse (as defined by the Investigator) within 1 year prior to Study Day 1.
• Active bacterial or viral infection.
• Use of marijuana within 2 months prior to Study Day 1or at any time during the study
• Alcohol consumption within 24 hours of either test session.
• Unable to comply with study requirements.
• Expected survival time of less than 3 months.