Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Microcirculatory Changes During Open Label Magnesium Sulphate Infusion in Severe Sepsis and Septic Shock|
- microvascular flow index [ Time Frame: 1 hour ] [ Designated as safety issue: No ]Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.
|Study Start Date:||March 2010|
|Study Completion Date:||January 2011|
|Primary Completion Date:||August 2010 (Final data collection date for primary outcome measure)|
|severe sepsis and septic shock||
Drug: Magnesium Sulfate
2 gram in 1 hour
In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01332734
|Hospital of Lithuanian university of health sciences|
|Kaunas, Lithuania, LT 44307|
|Principal Investigator:||A Pranskunas, MD||Lithuanian university of sciences|