Phospholipid Absorption of a Milk Phospholipid
The aim of the study is to investigate parameters of the lipid metabolism in plasma and feces of healthy subjects after a dietary supplementation of different dosages of milk phospholipids.
|Study Design:||Endpoint Classification: Bio-availability Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Effect of a Milk Phospholipid Supplementation on the Lipid Metabolism in Healthy Volunteers|
- Change in plasma phospholipid concentration [ Time Frame: after 0, 10, 20, and 30 days ] [ Designated as safety issue: Yes ]
Total phospholipid concentration
Individual phospholipid concentration (lyso phosphatidylcholine, phosphatidylcholine, sphingomyelin, phosphatidylethanolamine, phosphatidylinositol)
- Plasma lipids [ Time Frame: after 0,10,20, and 30 days ] [ Designated as safety issue: Yes ]
Fatty acid fraction (total fatty acid distribution, phospholipid fatty acid distribution)
Cholesterol fraction (total cholesterol, LDL cholesterol, HDL cholesterol)
- Fecal lipids [ Time Frame: after 0,10,20, and 30 days ] [ Designated as safety issue: No ]Fecal lipids (crude fat, total phospholipids, sterols, bile acids)
|Study Start Date:||May 2010|
|Study Completion Date:||June 2010|
|Primary Completion Date:||June 2010 (Final data collection date for primary outcome measure)|
Experimental: Phospholipid supplementation
Supplementation of milk phospholipid
Dietary Supplement: Milk phospholipid
During day 1 until 10 the subjects were supplemented with daily 3 g milk phospholipids, during the day 11 and 20 the supplementation was increased to daily 6 g, and during the day 21 and 30 the subjects received daily 6 g milk phospholipids and 2 g of plant sterols.
To date the mechanisms for the intestinal absorption of glycerophosphates and sphingolipids are not completely investigated. It is assumed, that sphingolipids and sterols compete for intestinal absorption. In addition it is unclear, if a dietary phospholipid supplementation may influence the phospholipid concentration in plasma.
To evaluate the effect of a dietary phospholipid supplementation 15 healthy female subjects received over 10 days daily 3 g of milk phospholipids stirred in a dairy product. During the following 10 days the subjects were supplemented with daily 6 g milk phospholipid. Finally, the subjects received over 10 days 6 g of the milk phospholipid in a dairy product and 2 g of plant sterols serving a commercial product.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01327430
|Friedrich Schiller University of Jena, Department of Nutritional Physiology|
|Jena, Thuringia, Germany, 07743|
|Principal Investigator:||Gerhard Jahreis, Prof. Dr.||Friedrich Schiller University, Department of Nutritional Physiology|