Late-Life Depression

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2011 by University of Illinois at Chicago.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Information provided by:
University of Illinois at Chicago
ClinicalTrials.gov Identifier:
NCT01327417
First received: March 30, 2011
Last updated: March 31, 2011
Last verified: March 2011
  Purpose

The purpose of the study is to examine the relationship between brain structure and depression in adults aged 60 or older. This relationship is determined using magnetic resonance imaging technology (MRI), a scanner with a magnet that is used to create images of the brain.


Condition
Depression

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Cortical/Subcortical Circuits in Late-Life Depression

Resource links provided by NLM:


Further study details as provided by University of Illinois at Chicago:

Estimated Enrollment: 400
Study Start Date: September 2009
Estimated Study Completion Date: April 2013
Estimated Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Depressed
Patients with Major Depressive Disorder
Healthy Controls

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
  • Geriatric Medicine and Psychiatry clinics within the UIC Medical Center. Patients with mood and other psychiatric disturbances are frequently referred by physicians from both geriatric medicine and family medicine for a consultation and sometimes for ongoing psychiatric care.
  • Community outreach efforts and recruitment through advertising in newsletters, local newspapers
Criteria

Inclusion Criteria:

  • Age: 60 years or greater
  • Diagnosis of major depressive disorder using standard diagnostic and statistical manual (DSM) criteria
  • Score of 15 or greater on the 17-item Hamilton Depression rating scale
  • Mini Mental Status Exam score of 24 or greater
  • No evidence of clinical dementia or any other clinical brain disorder
  • Free of psychotropic/psychoactive medications for at least 2 weeks

Exclusion Criteria:

  • Presence of dementia or any other clinical brain disorder (Parkinson's, Alzheimer's)
  • History of progressive cognitive decline and/or Mini Mental Status Exam score of less than 24
  • Lifetime diagnosis of substance abuse
  • Unstable medical illness (grade 4 on the Cumulative Illness Rating Scale)
  • Presence of any metallic implant that would preclude an MRI scan (pacemaker, etc.)
  • Concurrent Axis 1 disorder (schizophrenia, bipolar)
  • Psychotropic medication implicated in depression i.e. Reserpine, Alpha methyl dopa, Beta blockers, multiple long acting benzodiazepines (valium, flurazepam, chlordiazepoxide), neuroleptics;
  • Seizure disorder
  • Stroke/Transient Ischemic Attack
  • Central nervous system disorder (Parkinson's disease, multiple sclerosis)
  • Trauma to head/Loss of Consciousness
  • Claustrophobia
  • Eating disorder (anorexia, bulimia)
  • Weight of over 350 pounds
  • Learning disorder (dyslexia, ADHD)
  • Psychosis, panic or anxiety disorder outside the context of depression
  • Mood stabilizing agents such as lithium and Divalproex sodium and antidepressants - as they have been shown to impact on brain levels of NAA, Ch and Ml
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01327417

Contacts
Contact: Piotr Daranowski, MA 312-413-8223 pdaranowski@psych.uic.edu
Contact: Monya Meinel, BA, CCRC 312-996-6201 mmeinel@psych.uic.edu

Locations
United States, Illinois
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: Monya Meinel, BA, CCRC    312-996-6201    mmeinel@psych.uic.edu   
Sponsors and Collaborators
University of Illinois at Chicago
Investigators
Principal Investigator: Anand Kumar, MD University of Illinois at Chicago
  More Information

Additional Information:
Publications:
Responsible Party: Anand Kumar, MD, Head of Psychiatry, University of Illinois
ClinicalTrials.gov Identifier: NCT01327417     History of Changes
Other Study ID Numbers: 2009-0613, R01MH073989
Study First Received: March 30, 2011
Last Updated: March 31, 2011
Health Authority: United States: Institutional Review Board
United States: Federal Government

Keywords provided by University of Illinois at Chicago:
Depression

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on August 28, 2014