Early Aggressive Correction of Severe Acidosis With Tris-hydroxymethylaminomethane (THAM)
Recruitment status was Recruiting
This study involved the medical record review of resuscitation records for all severely-injured trauma patients requiring emergent surgical intervention and significant acidosis from 2005 through 2009.
Resuscitation, Trauma Patients
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Early Aggressive Correction of Severe Acidosis With Tris-hydroxymethylaminomethane (THAM) in Patients With Severe Traumatic Injury: A Retrospective Cohort Study|
- Total amount of fluids and blood products used during the operative and 72 hr post-operative period. [ Time Frame: Operative period and ICU (72 hr) post-op period ] [ Designated as safety issue: No ]Total amount of fluids and blood products used during the operative and 72 hr post-operative period.
- Intra-operative, intensive care unit and hospital mortality [ Time Frame: From the operative procedure onset to discharge out of the ICU or expiration ] [ Designated as safety issue: No ]Measure the the number of mortality during intra-operative and/or ICU period
|Study Start Date:||July 2010|
|Estimated Study Completion Date:||July 2013|
|Estimated Primary Completion Date:||July 2013 (Final data collection date for primary outcome measure)|
Patients who were managed with the use of THAM
Patients who did not use THAM but were resuscitated with crystalloids and colloids and may have received sodium bicarbonate for the treatment of acidosis
The study objective is to assess the efficacy of fluid resuscitation and treatment of acidosis in patients who were managed with use of amine buffer THAM (tris-hydroxymethlaminomethane) versus those who were resuscitated with crystalloids or colloids and may have have received sodium bicarbonate for the treatment of acidosis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01326260
|Contact: Julin F Tang, MDemail@example.com|
|Contact: Gus Pangan, MBA||(415) firstname.lastname@example.org|
|United States, California|
|University of California, San Francisco at San Francisco General Hospital||Recruiting|
|San Francisco, California, United States, 94110|
|Contact: Julin Tang, MD 415-206-5274 email@example.com|
|Contact: Gus Pangan, MBA (415) 206-5274 firstname.lastname@example.org|
|Principal Investigator:||Julin Tang, MD||University of California, San Francisco|