Factors Related to the Progression of Chronic Kidney Disease
Recruitment status was Active, not recruiting
Chronic kidney disease is a progressive disorder that has been influenced with many factors. Most of the patients has altered Ca P metabolism and these dis orders are the contributing factors of the disease progression. It has been recently documented that FGF23 and Klotho are the key factors of PTH secretion Ca-P metabolism. This study aimed to evaluate the impact of Klotho and FGF23 on the progression of stage 3-4 chronic kidney disease.
Chronic Kidney Disease
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||The Impact of FGF23 and Klotho on Progression of Chronic Kidney Disease|
- Progression of kidney disease [ Time Frame: continuous measurement of kidney functions 3 monthly for two years or until the outcome reached ] [ Designated as safety issue: Yes ]Doubling of creatinin, requirement of renal replacement therapy
- Evaluation of Ca P metabolism [ Time Frame: 3 monthly for two years or until the outcome reached ] [ Designated as safety issue: No ]Determination of Ca-P metabolism disorders.
|Study Start Date:||March 2008|
|Estimated Study Completion Date:||June 2011|
|Estimated Primary Completion Date:||May 2011 (Final data collection date for primary outcome measure)|
Serum creatinin level rise more than 2 times
Serum creatinin level rise less than 2 times