Effects of Joint Effusion on Quadriceps Muscle - Full Text View

Purpose

The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).

Condition	Intervention
Knee Osteoarthritis	Other: normal saline injection Other: sham injection

Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single Blind (Investigator) Primary Purpose: Basic Science
Official Title:	Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis

Resource links provided by NLM:

MedlinePlus related topics: Osteoarthritis

U.S. FDA Resources

Further study details as provided by The Catholic University of Korea:

Primary Outcome Measures:

the peak torque of the knee extensors [ Time Frame: within 5 minutes after intervention ] [ Designated as safety issue: No ]
to evaluate the effect of effusion on the peak torque of the knee extensors

Secondary Outcome Measures:

the root mean square values of the vastus medialis and vastus lateralis muscles [ Time Frame: within 5 minutes after intervention ] [ Designated as safety issue: No ]
to evaluate the effect of effusion on the RMS of the vastus medialis (VM) and vastus lateralis (VL) muscles

Enrollment:	40
Study Start Date:	June 2009
Study Completion Date:	June 2010
Primary Completion Date:	January 2010 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Active Comparator: normal saline injection 20 cc normal saline injection into the knee joint	Other: normal saline injection 20 cc normal saline injection into knee joint Other Name: normal saline
Sham Comparator: sham injection knee injection without saline	Other: sham injection no saline injection Other Name: no normal saline

Detailed Description:

Several studies have shown that knee effusion influenced quadriceps muscle activity and induced quadriceps arthrogenic muscle inhibition in normal volunteers. However, the effect of joint effusion on the quadriceps of patients with OA is controversial,and few patients with OA have been included in studies of joint effusion.

Eligibility

Ages Eligible for Study:	50 Years to 75 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

50 years old or older with knee osteoarthritis
knee pain without joint effusion confirmed by ultrasonography

Exclusion Criteria:

the presence of knee joint effusion determined using US
a history of knee injury or surgery
a history of knee injection within 3 months
a history of inflammatory arthritis
taking anticoagulants
balance or gait disturbance
diabetes mellitus

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01314820

Locations

Korea, Republic of
Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
Seoul, Korea, Republic of, 137-701

Sponsors and Collaborators

The Catholic University of Korea

Investigators

Study Director:

Jongin Lee, M.D

Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea

More Information

Publications:

Fahrer H, Rentsch HU, Gerber NJ, Beyeler C, Hess CW, Grünig B. Knee effusion and reflex inhibition of the quadriceps. A bar to effective retraining. J Bone Joint Surg Br. 1988 Aug;70(4):635-8.

Jones DW, Jones DA, Newham DJ. Chronic knee effusion and aspiration: the effect on quadriceps inhibition. Br J Rheumatol. 1987 Oct;26(5):370-4.

Rice D, McNair PJ, Dalbeth N. Effects of cryotherapy on arthrogenic muscle inhibition using an experimental model of knee swelling. Arthritis Rheum. 2009 Jan 15;61(1):78-83.

Responsible Party:	Department of Rehabilitation Medicine, Seoul St. Mary's Hospital,, College of Medicine, The Catholic University of Korea
ClinicalTrials.gov Identifier:	NCT01314820 History of Changes
Other Study ID Numbers:	KC09OISI0161
Study First Received:	March 14, 2011
Last Updated:	March 14, 2011
Health Authority:	Korea: Institutional Review Board

Keywords provided by The Catholic University of Korea:

Knee
Osteoarthritis
Effusion.

Additional relevant MeSH terms:

Osteoarthritis
Osteoarthritis, Knee
Hydrarthrosis
Arthritis

Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on June 17, 2013