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Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Rennes University Hospital
ClinicalTrials.gov Identifier:
NCT01311544
First received: March 7, 2011
Last updated: May 15, 2012
Last verified: May 2012
  Purpose

The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic. An ultra-fast 3D MRA originally developed for the cardiac imaging, k-t blast (Broad-use Linear Acquisition Speed-up Technique) could be used to review the supraaortic vessels. This MRA offers the following advantages: short acquisition time, wide spatial coverage (of the thoracic aorta to the distal encephalic arteries), 3D spatial resolution and high temporal resolution. These qualities are even more optimal with a high magnetic field (3T). The high temporal resolution is interesting because it provides to repeat a volume every eight seconds and thus to have a dynamic evaluation of vascular filling and to assess the vascular supply of the infarcted territory. This sequence is classified as a 4D MRA.


Condition
Stroke, Acute

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients

Further study details as provided by Rennes University Hospital:

Primary Outcome Measures:
  • Images quality for each cervical and intracranial arteries [ Time Frame: 6 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Quantification of carotid stenosis with NASCET classification [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  • Study of dynamic vascular consequences of carotid stenosis [ Time Frame: 6 months ] [ Designated as safety issue: No ]

Enrollment: 92
Study Start Date: March 2011
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with acute ischemic stroke

Criteria

Inclusion Criteria:

  • Men and women over 18 years
  • Eligibility for intravenous thrombolytic treatment (National Institute of Neurological Disorders and Stroke criteria)
  • Permanent ischemic stroke confirm with encephalic MRI (Magnetic Resonance Imaging)
  • Patient able of accepting protocol information
  • Patient who received information about the protocol and had not expressed its opposition to participate

Exclusion Criteria:

  • Pacemaker
  • Surgical ferromagnetic clips
  • Cochlear implants
  • Intraocular metallic foreign body
  • Iron implants or objects likely to concentrate the Radio Frequency field
  • Claustrophobia
  • Known intolerance to contrast media (DOTAREM)
  • Pregnant women (Beta Human Chorionic gonadotrophin performed for biological assessment of thrombolysis)
  • Patient with severe kidney with Glomerular Filtration rate < 30 ml/min
  • Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01311544

Locations
France
Rennes University Hospital
Rennes, Brittany, France, 35033
Sponsors and Collaborators
Rennes University Hospital
Investigators
Principal Investigator: jean-yves gauvrit Rennes University Hospital
  More Information

No publications provided

Responsible Party: Rennes University Hospital
ClinicalTrials.gov Identifier: NCT01311544     History of Changes
Other Study ID Numbers: 2010-A01158-31, LOC/10-11
Study First Received: March 7, 2011
Last Updated: May 15, 2012
Health Authority: France: Comité consultatif sur le traitement de l'information en matière de recherche dans le domaine de la santé

Additional relevant MeSH terms:
Cerebral Infarction
Stroke
Brain Diseases
Brain Infarction
Brain Ischemia
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Nervous System Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on November 23, 2014