Circadian Sleep-wake Cycles and Light Therapy in Borderline Personality Disorder

This study has been completed.
Velux Fonden
Lumie UK
Information provided by:
University Hospital, Basel, Switzerland Identifier:
First received: March 3, 2011
Last updated: March 7, 2011
Last verified: March 2011

Individuals with borderline personality disorder (BPD) frequently suffer from emotional instability, daytime fatigue and sleep disturbances. The investigators examined circadian rhythms, sleep and well-being in women with BPD under their habitual life conditions with and without light treatment.

Treated women diagnosed with BPD were investigated during 3 weeks without and 3 weeks with morning LT. Rest-activity cycles were continuously measured using wrist actigraphy, together with proximal skin temperature. Saliva samples were collected weekly to determine the diurnal melatonin rhythm. A range of self-ratings and questionnaires were used to assess depression and clinical state throughout the 6-week protocol. Ten matched healthy women followed the same 6-week protocol without light treatment.

Condition Intervention
Borderline Personality Disorder
Sleep Disturbances
Other: light therapy

Study Type: Interventional
Official Title: Circadian Sleep-wake Cycles, Well-being and Light Therapy in Borderline Personality Disorder

Resource links provided by NLM:

Further study details as provided by University Hospital, Basel, Switzerland:

Arms Assigned Interventions
Experimental: light therapy
Morning bright light treatment (at 8000 lux for 40min, daily during 3 weeks)
Other: light therapy
early morning exposures to bright light, 8000lux for 40min, daily during 3 weeks


Ages Eligible for Study:   20 Years to 45 Years
Genders Eligible for Study:   Female

Inclusion Criteria:

  • Borderline Personality Disorder (DSM IV-criteria)
  • German-speaking
  • normal ocular function

Exclusion Criteria:

  • lack of compliance
  Contacts and Locations
Please refer to this study by its identifier: NCT01311193

Centre for Chronobiology, Psychiatric Hospital, University of Basel
Basel, BS, Switzerland, 4012
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Velux Fonden
Lumie UK
Principal Investigator: Christian Cajochen, PhD Centre for Chronobiology, Psychiatric Hospital, University of Basel
  More Information

Additional Information:
No publications provided Identifier: NCT01311193     History of Changes
Other Study ID Numbers: Velux-425
Study First Received: March 3, 2011
Last Updated: March 7, 2011
Health Authority: Switzerland: Ethikkommission

Keywords provided by University Hospital, Basel, Switzerland:
Circadian rhythms
Sleep-wake cycles
Borderline Personality Disorder
Light therapy

Additional relevant MeSH terms:
Personality Disorders
Borderline Personality Disorder
Depressive Disorder
Sleep Disorders
Mental Disorders
Behavioral Symptoms
Mood Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms processed this record on April 17, 2014