Circadian Sleep-wake Cycles and Light Therapy in Borderline Personality Disorder

This study has been completed.
Sponsor:
Collaborators:
Velux Fonden
Lumie UK
Information provided by:
University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:
NCT01311193
First received: March 3, 2011
Last updated: March 7, 2011
Last verified: March 2011
  Purpose

Individuals with borderline personality disorder (BPD) frequently suffer from emotional instability, daytime fatigue and sleep disturbances. The investigators examined circadian rhythms, sleep and well-being in women with BPD under their habitual life conditions with and without light treatment.

Treated women diagnosed with BPD were investigated during 3 weeks without and 3 weeks with morning LT. Rest-activity cycles were continuously measured using wrist actigraphy, together with proximal skin temperature. Saliva samples were collected weekly to determine the diurnal melatonin rhythm. A range of self-ratings and questionnaires were used to assess depression and clinical state throughout the 6-week protocol. Ten matched healthy women followed the same 6-week protocol without light treatment.


Condition Intervention
Borderline Personality Disorder
Sleep Disturbances
Depression
Other: light therapy

Study Type: Interventional
Official Title: Circadian Sleep-wake Cycles, Well-being and Light Therapy in Borderline Personality Disorder

Resource links provided by NLM:


Further study details as provided by University Hospital, Basel, Switzerland:

Arms Assigned Interventions
Experimental: light therapy
Morning bright light treatment (at 8000 lux for 40min, daily during 3 weeks)
Other: light therapy
early morning exposures to bright light, 8000lux for 40min, daily during 3 weeks

  Eligibility

Ages Eligible for Study:   20 Years to 45 Years
Genders Eligible for Study:   Female
Criteria

Inclusion Criteria:

  • Borderline Personality Disorder (DSM IV-criteria)
  • German-speaking
  • normal ocular function

Exclusion Criteria:

  • lack of compliance
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01311193

Locations
Switzerland
Centre for Chronobiology, Psychiatric Hospital, University of Basel
Basel, BS, Switzerland, 4012
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Velux Fonden
Lumie UK
Investigators
Principal Investigator: Christian Cajochen, PhD Centre for Chronobiology, Psychiatric Hospital, University of Basel
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT01311193     History of Changes
Other Study ID Numbers: Velux-425
Study First Received: March 3, 2011
Last Updated: March 7, 2011
Health Authority: Switzerland: Ethikkommission

Keywords provided by University Hospital, Basel, Switzerland:
Circadian rhythms
Sleep-wake cycles
Melatonin
Borderline Personality Disorder
Light therapy

Additional relevant MeSH terms:
Personality Disorders
Borderline Personality Disorder
Depression
Depressive Disorder
Sleep Disorders
Dyssomnias
Parasomnias
Mental Disorders
Behavioral Symptoms
Mood Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms

ClinicalTrials.gov processed this record on August 26, 2014