Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2011 by China Medical University Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
China Medical University, China
Information provided by:
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01310907
First received: March 6, 2011
Last updated: NA
Last verified: March 2011
History: No changes posted
  Purpose

Bradyarrhythmia, including sinus node dysfunction and atrioventricular block, is a major cause necessitating pacemaker implantation. In contrast to familial bradyarrhythmia known as by mutations at particular ion channels, limited information is available for the mechanistic study in non-familial bradyarrhythmia.

Possible gene polymorphisms related to non-familial bradyarrhythmia were studied. Comparison of multi-locus analysis and single-locus analysis will be analyzed between the cases and controls. Functional studies will perform to clarify the results of association study.


Condition
Bradyarrhythmia

Study Type: Observational

Further study details as provided by China Medical University Hospital:

Estimated Enrollment: 400
Study Start Date: February 2011
Groups/Cohorts
sinus node dysfunction
Atrioventricular block
control

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

The case group include 200 patients and the control group include 200 patients.

Criteria

Inclusion Criteria:

  • The patients with non-familial bradyarrhythmia

Exclusion Criteria:

  • Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01310907

Contacts
Contact: Jan-Yow Chen, MD +422052121 ext 2311 janyow@ms77.hinet.net

Locations
Taiwan
China Medical University Hospital Recruiting
Taichung, Taiwan, 404
Contact: Jan-Yow Chen, MD    +88622052121 ext 2311    janyow@ms77.hinet.net   
Principal Investigator: Jan-Yow Chen, MD         
China Medical University Hospital Recruiting
Taichung, Taiwan, 404
Contact: Jan-Yow Chen, MD    +886-4-22052121 ext 2311    janyow@ms77.hinet.net   
Principal Investigator: Jan-Yow Chen, MD         
Sponsors and Collaborators
China Medical University Hospital
China Medical University, China
Investigators
Principal Investigator: Jan-Yow Chen, MD China Medical University Hospital
  More Information

Additional Information:
Publications:
Responsible Party: Jan-Yow Chen M.D., China Medical University Hospital
ClinicalTrials.gov Identifier: NCT01310907     History of Changes
Other Study ID Numbers: DMR99-IRB-315
Study First Received: March 6, 2011
Last Updated: March 6, 2011
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Bradycardia
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on July 28, 2014