Unknown Glucose Metabolism Disorders In Patients With Coronary Artery Disease

This study has been completed.
Sponsor:
Information provided by:
Gulhane School of Medicine
ClinicalTrials.gov Identifier:
NCT01310556
First received: March 7, 2011
Last updated: June 17, 2011
Last verified: June 2009
  Purpose

This study aimed to examine the prevalence of glucose metabolism disorders (GMD)in the patients with coronary artery disease and the relationship between different GMDs and coronary artery disease (CAD).


Condition Intervention
Diabetes Mellitus
Other: ogtt for patients with coronary artery disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Relationship Between Previously Unknown Glucose Metabolism Disorders and Coronary Artery Disease in Patients Suffering From Coronary Artery Disease

Resource links provided by NLM:


Further study details as provided by Gulhane School of Medicine:

Primary Outcome Measures:
  • Frequency of unknown glucose metabolism disorders in patients with coronary artery disease [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
    Results: While GMDs were detected in 58.26% (n=134 patients) of CAD patients, 41.74% of them (n=96 patients) were found to have normal glucose metabolism.


Secondary Outcome Measures:
  • Fasting and 120 minute glucose levels have relation with vessels' stenosis. [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
    Fasting glucose level was found to have a significant correlation with the total number of stenotic coronary vessels (p=0.0001) and the stenosis rate of all vessels . OGTT 120-minute glucose levels were found to have a significant correlation with the total number of stenotic coronary vessels and the stenosis rate of vessels with the exception of LAD.


Enrollment: 230
Study Start Date: June 2009
Study Completion Date: June 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
coronary artery disease
patients with coronary artery disease
Other: ogtt for patients with coronary artery disease
75 g OGTT
Other Name: no name

Detailed Description:

Context: There are more than 220 million people diagnosed with diabetes mellitus (DM) in the world. DM is a serious risk factor for coronary artery disease (CAD). This study aimed to examine the prevalence of glucose metabolism disorders (GMD) in te patients with coronary artery disease and the relationship between different GMDs and CAD.

Settings: 230 patients with coronary artery disease and without any known GMDs were included the study. Coronary angiography was used to diagnose CAD. Patients were administered the 75 g Oral Glucose Tolerance Test (OGTT).

  Eligibility

Ages Eligible for Study:   30 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

patients with coronary artery disease and who had no glucose metabolism disorders.

Criteria

Inclusion Criteria:

  • Patients with coronary artery disease and who had no glucose metabolism disorders were included to study.

Exclusion Criteria:

  • Patients who had previous GMDs, malignancies, chronic liver and kidney diseases, rheumatologic disorders, and a BMI higher than 35 kg/m2 were excluded from the study.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01310556

Locations
Turkey
Gulhane School of Medicine
Ankara, Turkey, 06100
Sponsors and Collaborators
Gulhane School of Medicine
Investigators
Study Director: Aydogan Aydogdu, MD Gulhane School of Medicine Ankara/Turkey
  More Information

No publications provided

Responsible Party: Gulhane School of Medicine, Dep. of Endocrinology and Metabolism
ClinicalTrials.gov Identifier: NCT01310556     History of Changes
Other Study ID Numbers: 12.05.2009-131-1068
Study First Received: March 7, 2011
Last Updated: June 17, 2011
Health Authority: Turkey: Ministry of Health

Keywords provided by Gulhane School of Medicine:
OGTT
coronary artery disease

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Diabetes Mellitus
Metabolic Diseases
Glucose Metabolism Disorders
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on July 29, 2014