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Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery (TRIMRIPC)

This study is currently recruiting participants.
Verified February 2012 by Norwegian University of Science and Technology
Sponsor:
Collaborator:
St. Olavs Hospital
Information provided by (Responsible Party):
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT01308138
First received: February 2, 2011
Last updated: February 15, 2012
Last verified: February 2012
History of Changes
  Purpose

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.


Condition Intervention
Myocardial Injury
 Behavioral: Exercise training
Procedure: remote ischemic preconditioning

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Basic Science
Official Title: Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Mitochondrial respiration [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
    Oxygraph (Strathkelvin)


Estimated Enrollment: 100
Study Start Date: January 2011
Estimated Study Completion Date: October 2013
Estimated Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: ExerciseTr Behavioral: Exercise training
exercise training
Experimental: Remote ischemic preconditioning group Procedure: remote ischemic preconditioning
remote ischemic preconditioning
No Intervention: Control patient group

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients undergoing coronary heart surgery and heart transplantation

Exclusion Criteria:

  • myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01308138

Locations
Norway
Norwegian University of Science and Technology, Medical Faculty Recruiting
Trondheim, Sør-Trondelag, Norway, 7489
Contact: Rognmo, PhD     +4772828080     oivind.rognmo@ntnu.no    
Sponsors and Collaborators
Norwegian University of Science and Technology
St. Olavs Hospital
Investigators
Principal Investigator: Katrine Hordnes, MD NTNU
  More Information

No publications provided

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT01308138     History of Changes
Other Study ID Numbers: TRIMRIPC
Study First Received: February 2, 2011
Last Updated: February 15, 2012
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Keywords provided by Norwegian University of Science and Technology:
Physical Activity
pathology
Physical Deconditioning

ClinicalTrials.gov processed this record on May 19, 2013