Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Lobectomy
The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary lobectomy.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Prevention
|Official Title:||Effect of Remote Ischemic Preconditioning on Lung Injury in Patients Undergoing Pulmonary Lobectomy:a Randomised Controlled Trial|
- Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy [ Time Frame: Jan,2012 ] [ Designated as safety issue: Yes ]Compared with the control group, patients in the LRIP group had significantly higher Cs and Cd , along with lower PA-aDO2 and RI at various phase (P<0.05). Serum concentration of IL-6,IL-8, TNF-ɑ and MDA in LRIP group were decreased significantly at postoperative time points compared with those in control group (P<0.05), but SOD was increased significantly at the same time (P<0.05).
|Study Start Date:||February 2011|
|Study Completion Date:||September 2012|
|Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
Adult patients undergoing elective pulmonary lobectomy were received a remote ischemic preconditioning group after induction of anaesthesia.
Procedure: remote ischemic preconditioning
Remote ischaemic preconditioning consisted of three 5-min cycles of right upper limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated.
Other Name: RIP
No Intervention: conventional
Adult patients undergoing pulmonary lobectomy were received no treatment after induction of anaesthesia.
Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary lobectomy, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.
|Departmeng of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University|
|GuangZhou, Guangdong, China, 510080|
|Principal Investigator:||Xuan Ke Liu, Ph.d||Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University|