Ultrasonography in Juvenile Idiopathic Arthritis
The purpose of this study is to analyse the usability of ultrasonography together with biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The investigators hypothesize that serum and urine markers of cartilage and bone synthesis and degradation, together with ultrasound measurements of joint cartilage thickness, are useful tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring methods.
Juvenile Idiopathic Arthritis, Oligoarthritis
Polyarticular Juvenile Rheumatoid Arthritis
Systemic Juvenile Idiopathic Arthritis
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Changes in Joint-Cartilage as a Measure of Outcome in Juvenile Idiopathic Arthritis - Assessed by Ultrasonography and Biomarkers|
- Joint cartilage thickness [ Time Frame: 1.5 years ] [ Designated as safety issue: No ]Joint catilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist
- Level of different biomarkers in serum and urine [ Time Frame: 1.5 years ] [ Designated as safety issue: No ]Level of bone- and cartilage-degradation biomarkers in serum and urine. COMP, CTX-II, RANKL/OPG, PYD/DPD
Biospecimen Retention: Samples Without DNA
Serum specimens taken for rutine markers of inflammation.
|Study Start Date:||October 2009|
|Study Completion Date:||November 2011|
|Primary Completion Date:||November 2011 (Final data collection date for primary outcome measure)|